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泊利噻嗪

泊利噻嗪用途

聚噻嗪是一种有效的口服噻嗪利尿剂,具有抗高血压作用。聚噻嗪可减轻水肿,降低血压。聚噻嗪还具有光毒性[1][2][3]。

泊利噻嗪名称

[ CAS 号 ]:
346-18-9

[ 中文名 ]:
泊利噻嗪

[ 英文名 ]:
polythiazide (200 mg)

[英文别名 ]:

泊利噻嗪生物活性

[ 描述 ]:

聚噻嗪是一种有效的口服噻嗪利尿剂,具有抗高血压作用。聚噻嗪可减轻水肿,降低血压。聚噻嗪还具有光毒性[1][2][3]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[体外研究]

在蓝光2000装置(Ex:325nm)下,聚噻嗪(500μM,1分钟)诱导显著的光毒性NHIK 3025细胞死亡[2]。

[体内研究]

聚噻嗪(口服灌胃,10 mg/kg,每日5天)增加了胆固醇喂养的C57BL/cdJ小鼠的血浆胆固醇水平[3]。多噻嗪(口服给药,0.4 mg/k g)对高血压狗和大鼠具有利尿和排尿作用[1]。动物模型：胆固醇喂养的C57BL/cdJ小鼠[3]剂量：10mg/kg给药：口服灌胃,每天5天结果：导致血浆总胆固醇水平上升约13%,非高密度脂蛋白分数增加。动物模型：高血压犬[1]剂量：0.4mg/kg给药：口服给药,每日5天结果：钠和氯的排泄增加。动物模型：高血压大鼠[1]剂量：0.05、0.1、0.2、0.4mg/kg给药：口服,每日两次,共3天。结果：显示利钠和利尿作用。

[参考文献]

[1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72.

[2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6.

[3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9.

泊利噻嗪物理化学性质

[ 密度 ]:
1.598g/cm3

[ 沸点 ]:
580.1ºC at 760mmHg

[ 熔点 ]:
202.5°

[ 分子式 ]:
C11H13ClF3N3O4S3

[ 分子量 ]:
439.88200

[ 闪点 ]:
304.7ºC

[ 精确质量 ]:
438.97100

[ PSA ]:
151.63000

[ LogP ]:
4.59280

[ 折射率 ]:
1.566

泊利噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK9275000
CHEMICAL NAME :
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl- 3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide
CAS REGISTRY NUMBER :
346-18-9
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H13-Cl-F3-N3-O4-S3
MOLECULAR WEIGHT :
439.90
WISWESSER LINE NOTATION :
T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
300 ug/kg/5D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes
REFERENCE :
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

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推荐生产厂家/供应商：

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2369.0/10mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

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