环丙喹宗

环丙喹宗用途

Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。

环丙喹宗名称

[ CAS 号 ]:
33453-23-5

[ 中文名 ]:
环丙喹宗

[ 英文名 ]:
Ciproquazone

[英文别名 ]:

环丙喹宗生物活性

[ 描述 ]:

Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。

[参考文献]

1. Vega S, et al. Thiophene isosteres: synthesis and biological evaluation of 3-substituted derivatives of 4-phenyl-2-thioxo-benzo [4, 5] thieno [2, 3-d] pyrimidine. European journal of medicinal chemistry, 1991, 26(3): 323-329.

环丙喹宗物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
483.8ºC at 760mmHg

[ 分子式 ]:
C19H18N2O2

[ 分子量 ]:
306.35800

[ 闪点 ]:
246.4ºC

[ 精确质量 ]:
306.13700

[ PSA ]:
44.12000

[ LogP ]:
3.48210

[ 折射率 ]:
1.653

环丙喹宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA3100333
CHEMICAL NAME :
2(1H)-Quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl-
CAS REGISTRY NUMBER :
33453-23-5
BEILSTEIN REFERENCE NO. :
0761592
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H18-N2-O2
MOLECULAR WEIGHT :
306.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979

环丙喹宗合成路线

详细合成路线

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