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替沃噻吨

替沃噻吨用途

(Z)-Thiothixene 是 serotonergic receptor 的拮抗剂,来自专利 US 20150141345 A1。

替沃噻吨名称

[ CAS 号 ]:
3313-26-6

[ 中文名 ]:
替沃噻吨

[ 英文名 ]:
(Z)-Thiothixene

[中文别名 ]:

[英文别名 ]:

Thiothixene
MFCD00079574
cis-Thiothixene
(Z)-Thiothixene

替沃噻吨生物活性

[ 描述 ]:

(Z)-Thiothixene 是 serotonergic receptor 的拮抗剂,来自专利 US 20150141345 A1。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[ 靶点 ]

serotonergic receptor[1]

[体外研究]

(Z)-Thiothixene能够促进细胞存活和/或可塑性,和/或抑制细胞死亡,特别是当毒性剂暴露于细胞,包括神经细胞时[1]。 (Z)-Thiothixene是thiothixene的Z(顺式)异构体,以及合成前体和降解产物[2]。

[参考文献]

[1]. Illana Gozes, et al. Novel compounds and methods for inhibiting cell death. US 20150141345 A1.

[2]. Severin G. Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples. J Pharm Sci. 1987 Mar;76(3):231-4.

[相关活性小分子]

替沃噻吨物理化学性质

[ 密度 ]:
1.269 g/cm3

[ 沸点 ]:
599ºC at 760 mmHg

[ 熔点 ]:
114-118ºC

[ 分子式 ]:
C₂₃H₂₉N₃O₂S₂

[ 分子量 ]:
443.62500

[ 闪点 ]:
316.1ºC

[ 精确质量 ]:
443.17000

[ PSA ]:
77.54000

[ LogP ]:
4.42730

[ 外观性状 ]:
黄色带有一种黄褐色的粉末

[ 折射率 ]:
1.643

[ 储存条件 ]:
2-8°C

替沃噻吨MSDS

详细MSDS(安全技术说明书)

替沃噻吨毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XO1420000

CHEMICAL NAME :: Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene )-, (Z)-

CAS REGISTRY NUMBER :: 3313-26-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H29-N3-O2-S2

MOLECULAR WEIGHT :: 443.67

WISWESSER LINE NOTATION :: T C666 BS IYJ FSWN1&1 IU3- AT6N DNTJ D1 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,17,1970

替沃噻吨安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
XO1420000