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唾液

唾液用途

CMP唾液酸(CMP-Neu5Ac)是UDP-GlcNAc 2-二聚体酶的变构抑制剂。CMP唾液酸为高尔基唾液酸转移酶提供了底物。CMP唾液酸是唾液酸及其缀合物生物合成的重要糖核苷酸[1]。

唾液名称

[ CAS 号 ]:
3063-71-6

[ 中文名 ]:
唾液

[ 英文名 ]:
Cytidine 5'-monophosphate-N-acetylneuraminic acid

[中文别名 ]:

[英文别名 ]:

CMP-b-D-Sialic Acid,DisodiumSalt
CMP-NAN,CMP-NANA,CMP-NeuAc,CMP-Sialic acid
CMP-Sia
CMP-N-acetyl-beta-neuraminic acid
Cytidine monophosphate n-acetylneuraminic acid
cytidine 5-monophospho-N-*acetylneuraminic acid
CYTIDINE 5'-MONOPHOSPHO-N-
cytidine-5'-monophospho-N-acetyl-D-neuraminic acid
cmp-nan
CMP-N-Acetylneuraminic Acid

唾液生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

CMP唾液酸(22.5μM,45分钟)可用作厘米小时底物来检测血小板裂解物中 Neu5Gc公司的形成[1]。

[参考文献]

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5.

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795.

唾液物理化学性质

[ 密度 ]:
2.02g/cm3

[ 分子式 ]:
C₂₀H₃₀N₄NaO₁₆P

[ 分子量 ]:
636.433

[ 精确质量 ]:
636.129211

[ PSA ]:
335.55000

[ 折射率 ]:
1.737

[ 储存条件 ]:
-20°C，干燥，密封

[ 水溶解性 ]:
Freely soluble (220 g/L) (25 ºC)

唾液MSDS

唾液安全信息

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

唾液合成路线

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唾液文献

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.

Nat. Commun. 6 , 6651, (2015)

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sia...

In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.

PLoS ONE 10 , e0134949, (2015)

The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of monoclo...

A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalized modules for membrane antigens (GMMA).

Vaccine 32(23) , 2688-95, (2014)

Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing to the burden ...

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唾液