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1-(4-氯二苯基)哌嗪

1-(4-氯二苯基)哌嗪用途

1-(4-氯苯甲醛)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

1-(4-氯二苯基)哌嗪名称

[ CAS 号 ]:
303-26-4

[ 中文名 ]:
1-(4-氯二苯甲基)哌嗪

[ 英文名 ]:
UNII:T875VN0D6E

[中文别名 ]:

[英文别名 ]:

EINECS 206-137-4
N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
Hydroxyzine Related Compound A
1-(α-Phenyl-4-chlorobenzyl)piperazine
Norchlorcyclizine
1-(4-Chlorobenzhydry)piperazine
1-((4-Chlorophenyl)(phenyl)methyl)piperazine
1-[(4-Chlorophenyl)(phenyl)methyl]piperazine
1-(4-Chlorobenzhydryl) piperazine
1-(4-Chloro-α-phenylbenzyl)piperazine

1-(4-氯二苯基)哌嗪生物活性

[ 描述 ]:

1-(4-氯苯甲醛)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

1-(4)-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物,在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4)-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7(Nav1.7)抑制剂、抗癌剂和抗组胺剂。

[参考文献]

[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973)

[2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965)

[3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996)

[4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014)

[5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015)

[6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012)

[7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

1-(4-氯二苯基)哌嗪物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
409.1±0.0 °C at 760 mmHg

[ 熔点 ]:
65-70 °C(lit.)

[ 分子式 ]:
C₁₇H₁₉ClN₂

[ 分子量 ]:
286.80

[ 闪点 ]:
193.3±26.5 °C

[ 精确质量 ]:
286.123688

[ PSA ]:
15.27000

[ LogP ]:
3.44

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.592

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
可溶于：甲醇

1-(4-氯二苯基)哌嗪MSDS

1-(4-氯二苯基)哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1772000

CHEMICAL NAME :: Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-

CAS REGISTRY NUMBER :: 303-26-4

BEILSTEIN REFERENCE NO. :: 0243027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H19-Cl-N2

MOLECULAR WEIGHT :: 286.83

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

1-(4-氯二苯基)哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TL1772000

[ 海关编码 ]:
2933599090

1-(4-氯二苯基)哌嗪合成路线

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1-(4-氯二苯基)哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%