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醋羟孕酮

醋羟孕酮用途

17α-羟基孕酮醋酸酯具有孕酮活性。17α-羟基孕酮醋酸酯在小鼠母胎界面具有抗炎作用[1][2]。

醋羟孕酮名称

[ CAS 号 ]:
302-23-8

[ 中文名 ]:
醋羟孕酮

[ 英文名 ]:
Hydroxyprogesterone acetate

[中文别名 ]:

[英文别名 ]:

17-Acetoxyprogesterone
17α-Acetoxyprogesterone
3,20-Dioxopregn-4-en-17-yl acetate
17a-Hydroxy-progesterone acetate
17ALPHA-ACETOXYPROGESTERONE
Prodox acetate
17α-Hydroxy-4-pregnene-3,20-dione 17-acetate
Chlormadinone acetate impurity G
Pregn-4-ene-3,20-dione, 1-(acetyloxy)-
17-Hydroxypregn-4-ene-3,20-dione acetate

醋羟孕酮生物活性

[ 描述 ]:

17α-羟基孕酮醋酸酯具有孕酮活性。17α-羟基孕酮醋酸酯在小鼠母胎界面具有抗炎作用[1][2]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

[体外研究]

17α-羟基孕酮(Delalutin)不是雄激素,它与孕酮和某些其他性类固醇一样,不会改变非生殖器官的发育[1]。

[参考文献]

[1]. R E Seegmiller, et al. Evaluation of the teratogenic potential of delalutin (17 alpha-hydroxyprogesterone caproate) in mice. Teratology. 1983 Oct;28(2):201-8.

[2]. Amy-Eunice Furcron, et al. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Dec;213(6):846.e1-846.e19.

醋羟孕酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
494.3±45.0 °C at 760 mmHg

[ 熔点 ]:
249-250ºC

[ 分子式 ]:
C₂₃H₃₂O₄

[ 分子量 ]:
372.498

[ 闪点 ]:
213.5±28.8 °C

[ 精确质量 ]:
372.230072

[ PSA ]:
60.44000

[ LogP ]:
3.41

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
Refrigerator

醋羟孕酮MSDS

详细MSDS(安全技术说明书)

醋羟孕酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5074000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate

CAS REGISTRY NUMBER :: 302-23-8

LAST UPDATED :: 199206

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C23-H32-O4

MOLECULAR WEIGHT :: 372.55

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1 FOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 72 mg/kg

SEX/DURATION :: male 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 896 mg/kg

SEX/DURATION :: female 32 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80500 ug/kg

SEX/DURATION :: female 23 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 ug/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

醋羟孕酮安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
22-24/25-45

[ 危险品运输编码 ]:
UN 2811 6

[ WGK德国 ]:
3

[ RTECS号 ]:
TU5074000