α-细辛脑
α-细辛脑用途
α-细辛脑名称
[ CAS 号 ]:
2883-98-9
[ 中文名 ]:
α-细辛醚
[ 英文名 ]:
alpha-Asarone
[中文别名 ]:
[英文别名 ]:
- Benzene, 1,2,4-trimethoxy-5-[(1E)-1-propen-1-yl]-
- trans-1,2,4-Trimethoxy-5-(1-propenyl)benzene
- Asarin
- 1,2,4-trimethoxy-5-[(1E)-prop-1-en-1-yl]benzene
- EINECS 220-743-6
- A-Asarion
- Asaron
- alpha-asarone
- (E)-Asarone
- benzene, 1,2,4-trimethoxy-5-[(1E)-1-propenyl]-
α-细辛脑生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
α-细辛脑物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
296.0±0.0 °C at 760 mmHg
[ 熔点 ]:
57-61 °C(lit.)
[ 分子式 ]:
C12H16O3
[ 分子量 ]:
208.254
[ 闪点 ]:
107.7±23.8 °C
[ 精确质量 ]:
208.109940
[ PSA ]:
27.69000
[ LogP ]:
2.98
[ 外观性状 ]:
单斜针状
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.526
[ 储存条件 ]:
−20°C
[ 水溶解性 ]:
水溶性:不溶;水溶解度:102 mg/l 25 °C;可溶于:乙醚,醇
α-细辛脑MSDS
α-细辛脑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DC2975000
- CHEMICAL NAME :
- Benzene, 1,2,4-trimethoxy-5-propenyl-, (E)-
- CAS REGISTRY NUMBER :
- 2883-98-9
- BEILSTEIN REFERENCE NO. :
- 1910606
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C12-H16-O3
- MOLECULAR WEIGHT :
- 208.28
- WISWESSER LINE NOTATION :
- 2U1R BO1 DO1 EO1 -T
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 418 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 66 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 176 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 156 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,269,1992 *** REVIEWS *** TOXICOLOGY REVIEW RICLAG Revista de Investigacion Clinica. (Instituto Nacional de la Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Deleq. Tlalpan, 14000 Mexico City, Mexico) V.1- 1948- Volume(issue)/page/year: 45,597,1993
α-细辛脑安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S22-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
DC2975000
[ 包装等级 ]:
II; III
[ 危险类别 ]:
4.1
α-细辛脑合成路线
α-细辛脑上下游产品
α-细辛脑上游产品
α-细辛脑下游产品
α-细辛脑文献
Phytomedicine 20(2) , 139-42, (2013)
Anti-Candida potential of Acorus calamus rhizome and its active principle, β-asarone, was evaluated against the human fungal pathogen, Candida albicans. β-Asarone exhibited promising growth inhibitory...
Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study.J. Ethnopharmacol. 144(2) , 305-12, (2012)
Recent studies have suggested that β-asarone have neuroprotective and cardiovascular protective effects in animal model. However, the influence of β-asarone on cerebrovascular system has not been expl...
Simultaneous determination ofα-,β- andγ-asarone inAcorus tatarinowiiby microemulsion electrokinetic chromatography with [BMIM]PF6as oil phaseTalanta 101 , 510-5, (2012)
In the present study, a rapid and repeatable microemulsion electrokinetic chromatography (MEEKC) method was developed for the simultaneous determination of three isomers (α-, β- and γ-asarone) in Acor...
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产品详情:α-Asarone
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标题:α-细辛脑_MSDS_用途_密度_CAS号【2883-98-9】_化源网 地址:https://www.chemsrc.com/amp/cas/2883-98-9_1027928.html