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烯丙菊酯

烯丙菊酯用途

S-生物丙烯菊酯是一种拟除虫菊酯杀虫剂。S-生物丙烯菊酯通过改变电压门控钠通道传导和非传导状态之间转换的门控动力学来破坏神经功能[1]。

烯丙菊酯名称

[ CAS 号 ]:
28434-00-6

[ 中文名 ]:
S-生物烯丙菊酯

[ 英文名 ]:
S-Bioallethrin

[中文别名 ]:

[英文别名 ]:

S-bioallethrin
EINECS 249-013-5
esdépalléthrine
esdepallethrine

烯丙菊酯生物活性

[ 描述 ]:

S-生物丙烯菊酯是一种拟除虫菊酯杀虫剂。S-生物丙烯菊酯通过改变电压门控钠通道传导和非传导状态之间转换的门控动力学来破坏神经功能[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

[参考文献]

[1]. McCavera SJ, et al. Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin. Neurotoxicology. 2012;33(3):384-390.

烯丙菊酯物理化学性质

[ 密度 ]:
1.05 g/cm3

[ 沸点 ]:
386.8ºC at 760 mmHg

[ 熔点 ]:
49.5ºC

[ 分子式 ]:
C₁₉H₂₆O₃

[ 分子量 ]:
302.40800

[ 闪点 ]:
166ºC

[ 精确质量 ]:
302.18800

[ PSA ]:
43.37000

[ LogP ]:
4.00200

[ 外观性状 ]:
透明至琥珀色粘性液体

[ 蒸汽压 ]:
3.46E-06mmHg at 25°C

[ 折射率 ]:
1.505 (25ºC)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
insoluble

烯丙菊酯MSDS

详细MSDS(安全技术说明书)

烯丙菊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ1472000

CHEMICAL NAME :: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, (+)-(E)-, ester with (+)- 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one

CAS REGISTRY NUMBER :: 28434-00-6

BEILSTEIN REFERENCE NO. :: 2059862

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C19-H26-O3

MOLECULAR WEIGHT :: 302.45

WISWESSER LINE NOTATION :: L5V BUTJ B2U1 C1 DOV- BL3TJ A1 A1 C1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - excitement Behavioral - ataxia

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 14,15,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/m3/3H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Kidney, Ureter, Bladder - other changes

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 14,15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 35,1315,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Behavioral - ataxia

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 14,15,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2720 mg/m3/3H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Kidney, Ureter, Bladder - other changes

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 14,15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,1451,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1545 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,78,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,78,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Behavioral - ataxia

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 20,217,1983 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

烯丙菊酯安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312-H330-H410

[ 警示性声明 ]:
P260-P280-P301 + P312 + P330-P304 + P340 + P310-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R20/22

[ 安全声明 (欧洲) ]:
36-60-61

[ 危险品运输编码 ]:
UN3082 9/PG 3

[ RTECS号 ]:
GZ1472000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2918300016

烯丙菊酯海关

[ 海关编码 ]: 2918300016

烯丙菊酯文献

Influence of pyrethroids and piperonyl butoxide on histamine release from isolated rat mast cells.

Inflamm. Res. 56(11) , 473-8, (2007)

Pyrethroids are insecticides with low acute toxicity in mammals but their world-wide use for domestic and occupational purposes has caused concern about the risks of long-term exposure. The mammalian ...

The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats.

Toxicol. Appl. Pharmacol. 216(2) , 354-62, (2006)

The default assumption that different pyrethroid insecticides, sharing a common mode of action, will show additivity of toxicity has not always been supported by in vitro measures, some of which have ...

Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin

Neurotoxicology 33(3) , 384-90, (2012)

Highlights ► We constructed Nav1.6Q3 sodium channels containing the IFM/QQQ mutation. ► Nav1.6Q3 channels expressed in Xenopus oocytes exhibited persistent activation. ► Opening of Nav1.6Q3 channels e...

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