DL-Α-甲基天冬氨酸

DL-Α-甲基天冬氨酸用途

α-甲基DL-天冬氨酸是精氨酸琥珀酸合成酶(ASS)的特异性抑制剂,也是1-瓜氨酸循环为1-精氨酸的限速酶[1]。

DL-Α-甲基天冬氨酸名称

[ CAS 号 ]:
2792-66-7

[ 中文名 ]:
Alpha-甲基-DL-天冬氨酸

[ 英文名 ]:
2-amino-2-methylsuccinic acid

[中文别名 ]:

DL-Α-甲基天冬氨酸

[英文别名 ]:

2-Amino-2-methylsuccinic acid
D-Aspartic acid,2-methyl-,hydrochloride (1:1)
2-Methylaspartic acid
MFCD00056709
Aspartic acid,2-methyl
2-Amino-2-methyl-bernsteinsaeure

DL-Α-甲基天冬氨酸生物活性

[ 描述 ]:

α-甲基DL-天冬氨酸是精氨酸琥珀酸合成酶(ASS)的特异性抑制剂,也是1-瓜氨酸循环为1-精氨酸的限速酶[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

α-甲基dl-天冬氨酸可显著降低SHR中Bj-BPP-10c的抗高血压活性[2]。

[体内研究]

α-甲基dl-天冬氨酸(147mg/kg,静脉注射)可减少l-瓜氨酸诱导的Wistar大鼠视网膜血管舒张[1]。动物模型：Wistar大鼠剂量：147mg/kg给药：147 mg/kg,静脉注射。结果：减轻L-瓜氨酸诱导的视网膜小动脉直径增加。

[参考文献]

[1]. Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23.

[2]. Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33.

DL-Α-甲基天冬氨酸物理化学性质

[ 熔点 ]:
232-234ºC

[ 分子式 ]:
C₅H₉NO₄

[ 分子量 ]:
147.12900

[ 精确质量 ]:
147.05300

[ PSA ]:
100.62000

[ 储存条件 ]:
室温，密闭，干燥

DL-Α-甲基天冬氨酸MSDS

详细MSDS(安全技术说明书)

DL-Α-甲基天冬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

DL-Α-甲基天冬氨酸上下游产品

DL-Α-甲基天冬氨酸上游产品

DL-Α-甲基天冬氨酸下游产品

DL-Α-甲基天冬氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

DL-Α-甲基天冬氨酸文献

Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.

Biochemistry 44(23) , 8218-29, (2005)

The mechanism for the reaction of aspartate aminotransferase with the C4 substrate, l-aspartate, has been well established. The binding of the C4 substrate induces conformational change in the enzyme ...

Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle.

Nitric Oxide 17 , 115-121, (2007)

Nitric oxide (NO) is an important vasorelaxant produced along with L-citrulline from L-arginine in a reaction catalyzed by endothelial nitric oxide synthase (eNOS). Previous studies suggested that the...

Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms.

J. Mol. Biol. 239(2) , 285-305, (1994)

Three crystal structures of wild type E. coli aspartate aminotransferase (E.C.2.6.1.1) in space group P2(1) have been determined at resolution limits between 2.6 and 2.35 A. The unliganded enzyme and ...

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