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N-甲基缬氨酸

N-甲基缬氨酸用途

N-甲基-DL-缬氨酸是缬氨酸衍生物,在芽中代谢为半胱氨酸、丙氨酸、酪氨酸、色氨酸、柠檬酸和琥珀酸。N-甲基-DL-缬氨酸参与修饰抗微管蛋白试剂单甲基极光抑素F(MMAF),使其疏水功能化并增加细胞通透性[1][2]。

N-甲基缬氨酸名称

[ CAS 号 ]:
2566-32-7

[ 中文名 ]:
N-甲基缬氨酸

[ 英文名 ]:
N-Methyl-DL-valine

[英文别名 ]:

methyl-valine
N-Methylvaline hydrochloride
N-METHYL-DL-VALINE HYDROCHLORIDE
Valine, N-methyl-, hydrochloride (1:1)
H-(S,R)-NMeVal-OH
N-ME-DL-VAL-OH HCL
N-Methyl-dl-valine,HCl
N-methyl-valine
N-Methylvaline hydrochloride (1:1)

N-甲基缬氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. M. Pasteels, et al. Uptake and metabolism of [14C]rinderine and [14C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions. Chemoecology. 2003;13:55–62.

[2]. Philip N Moquist, et al. Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux–positive Tumor Models. Mol Cancer Ther.2021;20(2): 320–328.

N-甲基缬氨酸物理化学性质

[ 密度 ]:
0.995

[ 熔点 ]:
82-84ºC

[ 分子式 ]:
C₆H₁₄ClNO₂

[ 分子量 ]:
167.634

[ 精确质量 ]:
167.071304

[ PSA ]:
49.33000

[ LogP ]:
1.50790

[ 储存条件 ]:
Store at RT.

N-甲基缬氨酸MSDS

详细MSDS(安全技术说明书)

N-甲基缬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

N-甲基缬氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

N-甲基缬氨酸文献

Investigation of 60Co γ-irradiated l-(−) malic acid, N-methyl-dl-valine and l-glutamic acid γ-ethyl ester by electron paramagnetic resonance technique Baskin, M.H., Aydin, M., and Osmanoğlu, S.

J. Mol. Struct. 983 , 200-202, (2010)

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