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聚甲基丙烯酸-2-羟乙酯

聚甲基丙烯酸-2-羟乙酯用途

聚甲基丙烯酸2-羟乙基酯(MW 1000000)是生物材料领域最重要的水凝胶之一。聚(2-甲基丙烯酸羟乙基酯)是隐形眼镜的基本成分,也用于软组织植入、软骨和骨的合成移植、神经组织再生、药物传递等[1]。

聚甲基丙烯酸-2-羟乙酯名称

[ CAS 号 ]:
25249-16-5

[ 中文名 ]:
聚(4-羟基-3-硝基苯乙烯)

[ 英文名 ]:
poly(2-hydroxyethyl methacrylate)

[英文别名 ]:

2-Hydroxyethyl methacrylate
MFCD00084374

聚甲基丙烯酸-2-羟乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

聚甲基丙烯酸2-羟乙基乙酯(PolyHEMA)保持与活组织相似的水分含量,并抵抗宿主细胞的降解和吸收。它可以很容易地制造成各种形状,并且可以很容易地消毒[1]。在聚甲基丙烯酸甲酯上培养的细胞增殖率降低；聚(2-甲基丙烯酸羟乙基酯)在hRPE培养物中不诱导细胞死亡。人视网膜色素上皮(RPE)细胞在聚甲基丙烯酸甲酯(2-羟乙基)上培养形成许多巨大的球状菌落。重新培养巨型菌落,并在聚(2-甲基丙烯酸羟乙基酯)细胞培养物中检测到视网膜祖细胞标记物和hRPE细胞标记物的存在[1]。

[参考文献]

[1]. Fatemeh Nazemroaya, et al. Induced Retro-Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA. J Cell Biochem. 2017 Oct;118(10):3080-3089.

聚甲基丙烯酸-2-羟乙酯物理化学性质

[ 密度 ]:
1.054g/cm3

[ 沸点 ]:
189ºC at 760mmHg

[ 分子式 ]:
C₆H₁₀O₃

[ 分子量 ]:
130.14200

[ 闪点 ]:
97.2ºC

[ 精确质量 ]:
130.06300

[ PSA ]:
46.53000

[ LogP ]:
0.09800

[ 外观性状 ]:
powder

[ 蒸汽压 ]:
0.159mmHg at 25°C

[ 折射率 ]:
1.442

[ 储存条件 ]:
室温，阴凉，干燥

[ 水溶解性 ]:
ethanol: 120 mg/mL

聚甲基丙烯酸-2-羟乙酯MSDS

详细MSDS(安全技术说明书)

聚甲基丙烯酸-2-羟乙酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

聚甲基丙烯酸-2-羟乙酯文献

Increased protein sorption in poly(acrylic acid)-containing films through incorporation of comb-like polymers and film adsorption at low pH and high ionic strength.

Langmuir 29(9) , 2946-54, (2013)

In principle, incorporation of comb-like block copolymers in multilayer polyelectrolyte films can both increase film thickness relative to coatings containing linear polymers and provide more swollen ...

Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis.

Proc. Natl. Acad. Sci. U. S. A. 110(25) , 10117-22, (2013)

Methacrylated hyaluronic acid (HA) hydrogels provide a backbone polymer with which mesenchymal stem cells (MSCs) can interact through several cell surface receptors that are expressed by MSCs, includi...

S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.

Exp. Dermatol. 24 , 342-8, (2015)

S100A7 is expressed in many squamous cell carcinomas (SCCs), such as SCC of the skin, and well-differentiated SCC always displays stronger staining of this protein. A431 cells, an epidermal cancer cel...

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