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右雷佐生

右雷佐生用途

Dexrazoxane(ICRF187)是心脏保护剂。

右雷佐生名称

[ CAS 号 ]:
24584-09-6

[ 中文名 ]:
右雷佐生

[ 英文名 ]:
Dexrazoxane

[中文别名 ]:

[英文别名 ]:

4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion
4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione)
(+)-4,4'-Propylenedi-2,6-piperazinedione
Dexrazoxane
Desrazoxane
Razoxane (+)-form
(S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione
Eucardion
MFCD00866449

右雷佐生生物活性

[ 描述 ]:

Dexrazoxane(ICRF187)是心脏保护剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[参考文献]

[1]. Jones, R.L., Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7.

[2]. Loyevsky, M., et al., Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol, 1999. 91(2): p. 105-14.

[相关活性小分子]

右雷佐生物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
531.5±50.0 °C at 760 mmHg

[ 熔点 ]:
194-196ºC

[ 分子式 ]:
C₁₁H₁₆N₄O₄

[ 分子量 ]:
268.269

[ 闪点 ]:
275.3±30.1 °C

[ 精确质量 ]:
268.117157

[ PSA ]:
98.82000

[ LogP ]:
-0.37

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
Desiccate at RT

右雷佐生MSDS

详细MSDS(安全技术说明书)

右雷佐生毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6390000

CHEMICAL NAME :: 2,6-Piperazinedione, 4,4'-propylenedi-, (+)-

CAS REGISTRY NUMBER :: 24584-09-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H16-N4-O4

MOLECULAR WEIGHT :: 268.31

WISWESSER LINE NOTATION :: T6VMV ENTJ EY1&U1- ET6VMV ENTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 383 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - liver function tests impaired Blood - leukopenia

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1250 mg/kg/5D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - hemorrhage Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1875 mg/kg/33D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 20 mg/L

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 1,283,1983

右雷佐生安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933599090

右雷佐生上下游产品

右雷佐生上游产品

右雷佐生下游产品

右雷佐生海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

右雷佐生文献

Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.

Mol. Pharmacol. 87(3) , 513-24, (2015)

Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a...

Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes.

PLoS ONE 10 , e0124643, (2015)

Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFB...

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.

PLoS ONE 9(10) , e109021, (2014)

Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established,...

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