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磺胺多辛

磺胺多辛用途

Sulfadoxine(Sulphadoxine)是长效的磺胺类化合物,常与pyrimethamine结合起到抗疟疾作用。

磺胺多辛名称

[ CAS 号 ]:
2447-57-6

[ 中文名 ]:
磺胺邻二甲氧嘧啶

[ 英文名 ]:
Sulfadoxine

[中文别名 ]:

[英文别名 ]:

sulphadoxin
Sulfadimoxine
ro4-4393
Sulphadoxine
SULFADOXIN
Sulfamethoxine
SulphodoxiMe
Sulformetoxine
fanzil
wr4873

磺胺多辛生物活性

[ 描述 ]:

Sulfadoxine(Sulphadoxine)是长效的磺胺类化合物,常与pyrimethamine结合起到抗疟疾作用。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html

[2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine

[相关活性小分子]

磺胺多辛物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
522.8±60.0 °C at 760 mmHg

[ 熔点 ]:
190-194ºC

[ 分子式 ]:
C₁₂H₁₄N₄O₄S

[ 分子量 ]:
310.329

[ 闪点 ]:
270.0±32.9 °C

[ 精确质量 ]:
310.073578

[ PSA ]:
124.81000

[ LogP ]:
0.34

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.623

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml

磺胺多辛MSDS

详细MSDS(安全技术说明书)

磺胺多辛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9500000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 2447-57-6

BEILSTEIN REFERENCE NO. :: 0625453

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H14-N4-O4-S

MOLECULAR WEIGHT :: 310.36

WISWESSER LINE NOTATION :: T6N CNJ DO1 EO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,37,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 gm/kg/15D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 gm/kg/26W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Related to Chronic Data - death

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

磺胺多辛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DA9500000

[ 海关编码 ]:
2935009090

磺胺多辛海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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J. Chromatogr. A. 1345 , 17-28, (2014)

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