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9H-吡啶[3,4-b]吲哚

9H-吡啶[3,4-b]吲哚用途

Norharmane (Norharman) 可从咖啡中分离得到,是一种有效的选择性单胺氧化酶 A (MAO-A) 抑制剂,Ki 为 3.34 μM。

9H-吡啶[3,4-b]吲哚名称

[ CAS 号 ]:
244-63-3

[ 中文名 ]:
去甲哈尔满

[ 英文名 ]:
Norharmane

[中文别名 ]:

[英文别名 ]:

Pyridoindole
CARBAZOLINE
b-carboline
β-carboline
MFCD00004956
betacarboline
Norharmane
9H-Pyrido[3,4-b]indole
EINECS 205-959-0
Nor Harmane

9H-吡啶[3,4-b]吲哚生物活性

[ 描述 ]:

Norharmane (Norharman) 可从咖啡中分离得到,是一种有效的选择性单胺氧化酶 A (MAO-A) 抑制剂,Ki 为 3.34 μM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[ 靶点 ]

MAO-A:3.34 μM (Ki)

Human Endogenous Metabolite

[参考文献]

[1]. Herraiz T, et al. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006 Jan 18;78(8):795-802.

[2]. Lee HW, et al. Potent Selective Inhibition of Monoamine Oxidase A by Alternariol Monomethyl Ether Isolated from Alternaria brassicae. J Microbiol Biotechnol. 2017 Feb 28;27(2):316-320.

9H-吡啶[3,4-b]吲哚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
391.3±15.0 °C at 760 mmHg

[ 熔点 ]:
219-221 ºC

[ 分子式 ]:
C₁₁H₈N₂

[ 分子量 ]:
168.195

[ 闪点 ]:
182.1±11.7 °C

[ 精确质量 ]:
168.068741

[ PSA ]:
28.68000

[ LogP ]:
2.80

[ 外观性状 ]:
淡黄色结晶

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.785

[ 储存条件 ]:
2-8°C

9H-吡啶[3,4-b]吲哚MSDS

9H-吡啶[3,4-b]吲哚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU9350000

CHEMICAL NAME :: 9H-Pyrido(3,4-b)indole

CAS REGISTRY NUMBER :: 244-63-3

BEILSTEIN REFERENCE NO. :: 0128414

LAST UPDATED :: 199803

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C11-H8-N2

MOLECULAR WEIGHT :: 168.21

WISWESSER LINE NOTATION :: T B656 EN HMJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2520 mg/kg/28D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2520 mg/kg

SEX/DURATION :: male 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 150 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,249,1983

9H-吡啶[3,4-b]吲哚安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36/37/39-S26-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UU9350000

[ 海关编码 ]:
2933990090

9H-吡啶[3,4-b]吲哚合成路线

9H-吡啶[3,4-b]吲哚上下游产品

9H-吡啶[3,4-b]吲哚上游产品

9H-吡啶[3,4-b]吲哚下游产品

9H-吡啶[3,4-b]吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

9H-吡啶[3,4-b]吲哚文献

Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.

Bioorg. Med. Chem. 16 , 3780, (2008)

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine v...

The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors

Bioorg. Med. Chem. 16 , 6689, (2008)

Twenty-three heterocyclic compounds were evaluated for their potential as trypanothione reductase inhibitors. As a result, the harmaline, 10-thiaisoalloxazine, and aspidospermine frameworks were ident...

Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: Evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO

Bioorg. Med. Chem. 19 , 7416-24, (2011)

Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic and exogenous amines and its inhibitors have therapeutic value for several conditions including affective disorders, stroke, neu...

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