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盐酸双马普利

盐酸双马普利用途

Dimaprit dihydrochloride 是一种选择性的组胺 H2 受体激动剂,它还抑制 nNOS,IC50 值为 49 μM。Dimaprit dihydrochloride 可刺激胃酸的分泌。

盐酸双马普利名称

[ CAS 号 ]:
23256-33-9

[ 中文名 ]:
S-(3-二甲氨基丙基)异硫脲二盐酸盐

[ 英文名 ]:
Dimaprit dihydrochloride

[中文别名 ]:

[英文别名 ]:

盐酸双马普利生物活性

[ 描述 ]:

Dimaprit dihydrochloride 是一种选择性的组胺 H2 受体激动剂,它还抑制 nNOS,IC50 值为 49 μM。Dimaprit dihydrochloride 可刺激胃酸的分泌。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 内分泌

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

H2 Receptor

nNOS:49 μM (IC50)

[体外研究]

Dimaprit在H1受体上的组胺活性小于0.0001%[1]。Dimaprit(0.1nm-100μM)抑制nNOS浓度依赖性,IC50为49±14μM[2]。

[体内研究]

迪马普利刺激大鼠(1.25μM/kg/min；快速静脉注射)、猫(2-64μM/h；静脉注射)和狗(1-100 nM/kg/min；静脉注射)的胃酸分泌[1]。Dimaprit(0.01-1μM/kg；每隔5分钟静脉注射)可引起猫血压的剂量依赖性下降。Dimaprit(1-100nm；动脉内注射)引起股血管床血管扩张,其(1μM/kg；推注或静脉注射)对心率无影响[1]。

[参考文献]

[1]. Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7.

[2]. Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4.

盐酸双马普利物理化学性质

[ 分子式 ]:
C₆H₁₇Cl₂N₃S

[ 分子量 ]:
234.19000

[ 精确质量 ]:
233.05200

[ PSA ]:
78.41000

[ LogP ]:
2.96880

[ 储存条件 ]:
-20°C，密封，干燥

盐酸双马普利MSDS

详细MSDS(安全技术说明书)

盐酸双马普利毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM3850000

CHEMICAL NAME :: Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-, dihydrochloride

CAS REGISTRY NUMBER :: 23256-33-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H15-N3-S.2Cl-H

MOLECULAR WEIGHT :: 234.22

WISWESSER LINE NOTATION :: MUYZS3N1&1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

盐酸双马普利安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2930909090

盐酸双马普利制备

盐酸双马普利海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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