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依他硝唑

依他硝唑用途

Etanidazole (SR 2508),一种 2-硝基咪唑化合物,是一种低氧放射增敏剂,可用于癌症诊断和化疗研究。

依他硝唑名称

[ CAS 号 ]:
22668-01-5

[ 中文名 ]:
依他硝唑

[ 英文名 ]:
Etanidazole

[英文别名 ]:

Etanidazol
Ethanidazole
Etanidazole
UNII:30DKA3Q1HL
Etanidazol [Spanish]
N-(2-hydroxyethyl)-2-nitroimidazole-1-acetamide
1-{N-(2-hydroxyethyl)-acetamido}-2-nitroimidazole
Radinyl
SR-2508
Etanidazolum

依他硝唑生物活性

[ 描述 ]:

Etanidazole (SR 2508),一种 2-硝基咪唑化合物,是一种低氧放射增敏剂,可用于癌症诊断和化疗研究。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Marcus KJ, et al. A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma. Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1182-5.

依他硝唑物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
354.3°C (rough estimate)

[ 熔点 ]:
162-163° (Beaman); mp 164.5-165° (Lee)

[ 分子式 ]:
C₇H₁₀N₄O₄

[ 分子量 ]:
214.179

[ 精确质量 ]:
214.070206

[ PSA ]:
112.97000

[ LogP ]:
-1.66

[ 折射率 ]:
1.646

[ 储存条件 ]:
2-8°C

依他硝唑MSDS

详细MSDS(安全技术说明书)

依他硝唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3355000

CHEMICAL NAME :: Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-

CAS REGISTRY NUMBER :: 22668-01-5

BEILSTEIN REFERENCE NO. :: 0919296

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H10-N4-O4

MOLECULAR WEIGHT :: 214.21

WISWESSER LINE NOTATION :: T5N CNJ A1VM2Q BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3716 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Musculoskeletal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 1 mmol/L/3D (Continuous)

REFERENCE :: 45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W., ed., New York, Masson Pub. USA, Inc., 1980 Volume(issue)/page/year: -,146,1980

依他硝唑安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ WGK德国 ]:
3

[ RTECS号 ]:
NI3355000

[ 海关编码 ]:
2933290090

依他硝唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

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[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%