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双羟萘酸噻嘧啶

双羟萘酸噻嘧啶用途

Pyrantel pamoate是一抗寄生虫感染化合物,去极化肌肉神经阻断剂。

双羟萘酸噻嘧啶名称

[ CAS 号 ]:
22204-24-6

[ 中文名 ]:
双羟萘酸噻嘧啶

[ 英文名 ]:
Pyrantel pamoate

[中文别名 ]:

双羟乃酸噻嘧啶

[英文别名 ]:

Embovin
Combantrin
Pyrantel embonate
MFCD00072037
pyrantel ptamoate
UNII-81BK194Z5M
Antiminth
CP-10,423-16
EINECS 244-837-1
Pyrantel pamoate

双羟萘酸噻嘧啶生物活性

[ 描述 ]:

Pyrantel pamoate是一抗寄生虫感染化合物,去极化肌肉神经阻断剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Salman AB. Management of intestinal obstruction caused by ascariasis. J Pediatr Surg. 1997 Apr;32(4):585-7.

[相关活性小分子]

双羟萘酸噻嘧啶物理化学性质

[ 沸点 ]:
642.7ºC at 760 mmHg

[ 熔点 ]:
266-267ºC

[ 分子式 ]:
C₃₄H₃₀N₂O₆S

[ 分子量 ]:
594.677

[ 闪点 ]:
356.5ºC

[ 精确质量 ]:
594.182434

[ PSA ]:
158.90000

[ LogP ]:
6.26020

[ 外观性状 ]:
无气味的淡黄色至黄褐色的结晶粉末无味道

[ 蒸汽压 ]:
2.13E-17mmHg at 25°C

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC

双羟萘酸噻嘧啶MSDS

详细MSDS(安全技术说明书)

双羟萘酸噻嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL2287000

CAS REGISTRY NUMBER :: 22204-24-6

LAST UPDATED :: 199506

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C23-H16-O6.C11-H14-N2-S

MOLECULAR WEIGHT :: 594.72

WISWESSER LINE NOTATION :: L66J CQ DVQ B1- BL66J CQ DVQ &T6N CN AUTJ C1 B1U1- BT5SJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >24 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 535 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >24 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1800 mg/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 180 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: female 7-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 5 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,79,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3221 No. of Facilities: 748 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 7070 (estimated) No. of Female Employees: 3365 (estimated)

双羟萘酸噻嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL2287000

[ 海关编码 ]:
2934999090

双羟萘酸噻嘧啶制备

双羟萘酸噻嘧啶海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

双羟萘酸噻嘧啶文献

Simultaneous determination of metformin and vildagliptin in human plasma by a HILIC-MS/MS method.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 965 , 133-41, (2014)

The objective of this work was to develop and validate a HILIC-MS/MS method for the simultaneous determination of metformin and vildagliptin in human plasma. Chromatographic separation was achieved us...

Canine generalized demodicosis treated with varying doses of a 2.5% moxidectin+10% imidacloprid spot-on and oral ivermectin: parasiticidal effects and long-term treatment outcomes.

Vet. Parasitol. 205(3-4) , 687-96, (2014)

Advocate(®) (2.5% moxidectin+10% imidacloprid) (Bayer HealthCare, Leverkusen, Germany) is a multiparasiticidal spot-on authorized for treating canine demodicosis in many countries. This blinded, rando...

Oxantel pamoate-albendazole for Trichuris trichiura infection.

N. Engl. J. Med. 370(7) , 610-20, (2014)

Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated...

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