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N-(2-羟丙基)甲基丙烯酰胺

N-(2-羟丙基)甲基丙烯酰胺用途

N-(2-Hydroxypropyl)methacrylamide 是用于合成共聚物,在内脏利什曼病 (VL) 中可靶向性递送抗衰老的药物。

N-(2-羟丙基)甲基丙烯酰胺名称

[ CAS 号 ]:
21442-01-3

[ 中文名 ]:
N-(2-羟丙基)甲基丙烯酰胺

[ 英文名 ]:
N-(2-HYDROXYPROPYL)METHACRYLAMIDE

[中文别名 ]:

N-(2-羟基丙基)甲基丙烯酰胺

[英文别名 ]:

1-methacryloylamino-2-hydroxypropane

N-(2-羟丙基)甲基丙烯酰胺生物活性

[ 描述 ]:

N-(2-Hydroxypropyl)methacrylamide 是用于合成共聚物,在内脏利什曼病 (VL) 中可靶向性递送抗衰老的药物。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体内研究]

在5 mg/kg体重的药物当量剂量下,含有溶酶体可降解侧链的所有N-(2-羟丙基)甲基丙烯酰胺共聚物药物共轭物显示出显著的体内抗利什曼原虫活性(>99%抑制率)[1]。

[参考文献]

[1]. Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. J Control Release. 2001 Dec 13;77(3):233-43.

[2]. Hao Tang, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science volume 36, pages1225-1238(2018).

N-(2-羟丙基)甲基丙烯酰胺物理化学性质

[ 密度 ]:
1.002g/cm3

[ 沸点 ]:
321.2ºC at 760mmHg

[ 熔点 ]:
70 °C

[ 分子式 ]:
C₇H₁₃NO₂

[ 分子量 ]:
143.18400

[ 闪点 ]:
148.1ºC

[ 精确质量 ]:
143.09500

[ PSA ]:
49.33000

[ LogP ]:
0.45040

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
2.43E-05mmHg at 25°C

[ 折射率 ]:
1.46

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免空气,加热

N-(2-羟丙基)甲基丙烯酰胺安全信息

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924199090

N-(2-羟丙基)甲基丙烯酰胺合成路线

详细合成路线

N-(2-羟丙基)甲基丙烯酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-(2-羟丙基)甲基丙烯酰胺文献

The influence of linker length on the properties of cathepsin S cleavable177Lu-labeled HPMA copolymers for pancreatic cancer imaging

Biomaterials 35(22) , 5760-70, (2014)

N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, ...

Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids.

Biomater. Sci. 3 , 1085-95, (2015)

Many attempts have been made in the application of multicellular tumor spheroids (MCTS) as a 3D tumor model to investigate their biological responses upon introduction of polymeric micelles as nanocar...

Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.

J. Neurosci. 34(35) , 11781-91, (2014)

The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission by filling vesicles with glutamate. At mammalian synapses, VGLUT expression level determines the amount of ...

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