<生产厂家价格>

奥苯达唑

奥苯达唑用途

Oxibendazole是广谱的驱虫剂。

奥苯达唑名称

[ CAS 号 ]:
20559-55-1

[ 中文名 ]:
奥苯达唑

[ 英文名 ]:
Oxibendazole

[中文别名 ]:

[英文别名 ]:

MFCD00801063
Oxibendazole
Oxbendazole
FENBENDAZOLE SULFOXIDE
Anthelcide EQ
Oxyibendazole
methyl 5-n-propoxybenzimidazole-2-carbamate
Anthdcide EQ
Methyl (5-propoxy-1H-benzimidazol-2-yl)carbamate
Oxbidazole

奥苯达唑生物活性

[ 描述 ]:

Oxibendazole是广谱的驱虫剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. http://en.wikipedia.org/wiki/Oxibendazole

[相关活性小分子]

奥苯达唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
459ºC

[ 熔点 ]:
230-231°C

[ 分子式 ]:
C₁₂H₁₅N₃O₃

[ 分子量 ]:
249.266

[ 精确质量 ]:
249.111343

[ PSA ]:
76.24000

[ LogP ]:
2.50

[ 外观性状 ]:
结晶固体

[ 折射率 ]:
1.635

[ 储存条件 ]:
2-8°C

奥苯达唑MSDS

奥苯达唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD0835000

CHEMICAL NAME :: Carbamic acid, (5-propoxy-1H-benzimidazol-2-yl)-, methyl ester

CAS REGISTRY NUMBER :: 20559-55-1

LAST UPDATED :: 199209

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H15-N3-O3

MOLECULAR WEIGHT :: 249.30

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GO3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - sex ratio

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 900 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 90 mg/kg

SEX/DURATION :: female 14-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2 mg/L

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

奥苯达唑安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FD0835000

[ 海关编码 ]:
2933990090

奥苯达唑合成路线

奥苯达唑上下游产品

奥苯达唑上游产品

奥苯达唑下游产品

奥苯达唑制备

4-乙酰胺基苯酚在氢氧化钾作用下，用溴丙烷烷基化，得到的化合物(I)再硝化引入硝基。然后水解为化合物(Ⅲ)，再用二氯化锡还原为二胺(Ⅳ)。接着和S-甲基硫脲环合为2-氨基苯并咪唑衍生物，再用氯甲酸甲酯酰化，即得奥苯达唑。

奥苯达唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

奥苯达唑文献

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors

Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009)

The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and keto...

更多文献