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N[6]-甲基-2'-脱氧腺苷

N[6]-甲基-2'-脱氧腺苷用途

N-6-甲基-2-脱氧腺苷是腺嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

N[6]-甲基-2'-脱氧腺苷名称

[ CAS 号 ]:
2002-35-9

[ 中文名 ]:
N6-甲基-2’-脱氧腺苷

[ 英文名 ]:
n6-methyl-2'-deoxy-adenosine

[中文别名 ]:

[英文别名 ]:

N-6-methyl-2'-deoxyribofuranosil adenine
N6-Methyl-2'-desoxy-adenosin
N6-Methyldeoxyadenosine
2'-Deoxy-N6-methylado
Adenosine,2'-deoxy-N-methyl
N6-Methyl-2'-deoxyadenosine
2'-deoxy-N6-methyladenosine
N6-methyl-2'-deoxy-adenosine

N[6]-甲基-2'-脱氧腺苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

N[6]-甲基-2'-脱氧腺苷物理化学性质

[ 密度 ]:
1.72g/cm3

[ 沸点 ]:
603.6ºC at 760mmHg

[ 分子式 ]:
C₁₁H₁₅N₅O₃

[ 分子量 ]:
265.27

[ 闪点 ]:
318.8ºC

[ 精确质量 ]:
265.11700

[ PSA ]:
105.32000

[ 外观性状 ]:
Powder | White to Off-white

[ 蒸汽压 ]:
2.03E-15mmHg at 25°C

[ 折射率 ]:
1.78

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in water

N[6]-甲基-2'-脱氧腺苷MSDS

N[6]-甲基-2'-脱氧腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29349990

N[6]-甲基-2'-脱氧腺苷合成路线

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N[6]-甲基-2'-脱氧腺苷文献

Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.

Br. J. Pharmacol. 171(14) , 3404-19, (2014)

Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood.We compared ...

GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat.

Neurosci. Lett. 584 , 168-72, (2014)

We examined ATP-induced intracellular Ca(2+) ([Ca(2+)]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated mod...

Pharmacological characterization of the human P2Y13 receptor.

Mol. Pharmacol. 64 , 104-112, (2003)

The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsivene...

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