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反式四氯二胺铂(IV)

反式四氯二胺铂(IV)名称

[ CAS 号 ]:
16893-06-4

[ 中文名 ]:
反式二氨基四氯化铂(IV)

[ 英文名 ]:
Platinum,diamminetetrachloro-, (OC-6-11)-

[中文别名 ]:

反式二氨基四氯化铂

[英文别名 ]:

trans-[PtCl4(NH3)2]
Tetrachloro-trans-diammin-platin(IV)
CIS-DIAMMINETETRACHLOROPLATINUM(IV)
trans-bisamminetetrachloroplatinum
trans Tetrachlorodiammine platinum
MFCD00050045
(e)-platinum(iv
trans-[Pt(NH3)2Cl4]
CIS-TETRACHLORODIAMMINE PLATINUM (IV)
{Pt<a2>Cl4}

反式四氯二胺铂(IV)物理化学性质

[ 熔点 ]:
>300ºC(lit.)

[ 分子式 ]:
Cl₄H₂N₂Pt++++

[ 分子量 ]:
366.91900

[ 精确质量 ]:
364.86200

[ PSA ]:
29.26000

[ LogP ]:
2.54650

[ 蒸汽压 ]:
5990mmHg at 25°C

[ 储存条件 ]:
2-8°C，密封，干燥

反式四氯二胺铂(IV)MSDS

详细MSDS(安全技术说明书)

反式四氯二胺铂(IV)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2485802

CHEMICAL NAME :: Platinum(IV), diamminetetrachloro-, (E)-

CAS REGISTRY NUMBER :: 16893-06-4

LAST UPDATED :: 199410

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: Cl4-H6-N2-Pt

MOLECULAR WEIGHT :: 370.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

反式四氯二胺铂(IV)安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317-H318-H334

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
UN 3288

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

反式四氯二胺铂(IV)文献

Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.

Cancer Res. 44(5) , 2043-51, (1984)

Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloropla...

Toxicity, mutagenicity and induction of recA protein in Escherichia coli treated with cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV).

Chem. Biol. Interact. 60(2) , 207-15, (1986)

After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magni...

Detection of DNA strand breaks in Escherichia coli treated with platinum(IV) antitumor compounds.

Chem. Biol. Interact. 74(3) , 343-52, (1990)

DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which...

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