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3-羟基呋喃丹

3-羟基呋喃丹用途

3-Hydroxycarbofuran 是 Carbofuran 的主要代谢物,是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。

3-羟基呋喃丹名称

[ CAS 号 ]:
16655-82-6

[ 中文名 ]:
3-羟基呋喃丹

[ 英文名 ]:
3-Hydroxy Carbofuran

[中文别名 ]:

[英文别名 ]:

Carbofuran-3-hydroxy solution
T56 BOT&J C1 C1 DQ IOVM1
MFCD00143168
Carbofuran-3-hydroxy
3-Hydroxycarbofuran

3-羟基呋喃丹生物活性

[ 描述 ]:

3-Hydroxycarbofuran 是 Carbofuran 的主要代谢物,是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[参考文献]

[1]. Duraisamy Kempuraj, et al. Carbofuran pesticide toxicity to the eye. Exp Eye Res. 2023 Feb;227:109355.

3-羟基呋喃丹物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
344.7±42.0 °C at 760 mmHg

[ 熔点 ]:
140-148ºC

[ 分子式 ]:
C₁₂H₁₅NO₄

[ 分子量 ]:
237.25

[ 闪点 ]:
162.2±27.9 °C

[ 精确质量 ]:
237.100113

[ PSA ]:
67.79000

[ LogP ]:
0.21

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
APPROX 4°C

3-羟基呋喃丹MSDS

3-羟基呋喃丹毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FB9500000

CHEMICAL NAME :: Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester

CAS REGISTRY NUMBER :: 16655-82-6

BEILSTEIN REFERENCE NO. :: 1383873

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H15-N-O4

MOLECULAR WEIGHT :: 237.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 mg/L

REFERENCE :: TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 18(1),17,1984

3-羟基呋喃丹安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+,Xi,F

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S28

[ 危险品运输编码 ]:
UN 2757

[ RTECS号 ]:
FB9500000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2932999099

3-羟基呋喃丹合成路线

3-羟基呋喃丹海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-羟基呋喃丹文献

Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry.

J. AOAC Int. 89(1) , 214-24, (2006)

A sensitive method using liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was developed and validated to quantify and confirm 13 pesticides, including aldicar...

Metabolism of carbofuran by Aspergillus niger and Fusarium graminearum.

J. Environ. Sci. Health B 33(3) , 253-66, (1998)

Metabolism of carbofuran in pure liquid cultures of A. niger and F. graminearum was investigated. Carbofuran and its metabolites were analyzed by HPLC and TLC. The average recoveries of carbofuran, 3-...

Surprising hair analysis results following acute carbofuran intoxication.

Forensic Sci. Int. 212(1-3) , e10-4, (2011)

We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined us...

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