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美他沙酮

美他沙酮用途

Metaxalone(AHR438;NSC170959)有肌肉松弛功能。

美他沙酮名称

[ CAS 号 ]:
1665-48-1

[ 中文名 ]:
美他沙酮

[ 英文名 ]:
Metaxalone

[中文别名 ]:

[英文别名 ]:

5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Metaxalone
5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
Metaxolone
MFCD00867700
5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone
Skelaxin
EINECS 216-777-6

美他沙酮生物活性

[ 描述 ]:

Metaxalone(AHR438;NSC170959)有肌肉松弛功能。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. http://en.wikipedia.org/wiki/Metaxalone

[相关活性小分子]

美他沙酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
453.6±14.0 °C at 760 mmHg

[ 熔点 ]:
121-123ºC

[ 分子式 ]:
C₁₂H₁₅NO₃

[ 分子量 ]:
221.252

[ 闪点 ]:
228.2±20.1 °C

[ 精确质量 ]:
221.105194

[ PSA ]:
47.56000

[ LogP ]:
2.42

[ 外观性状 ]:
发白的固体粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
-20°C Freezer

美他沙酮MSDS

美他沙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3850000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-

CAS REGISTRY NUMBER :: 1665-48-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H15-N-O3

MOLECULAR WEIGHT :: 221.28

WISWESSER LINE NOTATION :: T5MVOTJ D1OR C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 775 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 515 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1690 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972

美他沙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RQ3850000

美他沙酮合成路线

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美他沙酮文献

Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.

Clin. Ther. 26(9) , 1355-67, (2004)

Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support.The aim of this review was to discuss the etiology of low back pain an...

Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form.

Sci. Pharm. 80(2) , 353-66, (2012)

A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination o...

Metaxalone (Skelaxin)-related death.

J. Anal. Toxicol. 28(6) , 537-41, (2004)

The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatograp...

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