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1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚用途

四氢-β-卡宾(色氨酸)是色胺的代谢产物,也是一种竞争性5-羟色胺再摄取抑制剂,Ki值为6.1µM[1]。

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚名称

[ CAS 号 ]:
16502-01-5

[ 中文名 ]:
1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚

[ 英文名 ]:
Tryptoline

[中文别名 ]:

[英文别名 ]:

2,3,4,9-Tetrahydro-1H-β-carboline
Tetrahydro-b-carboline
Tetrahydro-β-carboline
1,2,3,4-Tetrahydro-b-carboline
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-
MFCD00004954
1,2,3,4-Tetrahydro-9H-Pyrido[3,4-B]Indole
Tetrahydro-beta-carboline
Triptoline

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚生物活性

[ 描述 ]:

四氢-β-卡宾(色氨酸)是色胺的代谢产物,也是一种竞争性5-羟色胺再摄取抑制剂,Ki值为6.1µM[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

serotonin:6.1 μM (Ki)

[体内研究]

四氢-β-卡宾(20µg；i.c.v.)增加了大鼠大脑同一部位的血清素水平[1]。动物模型：180-200g雌性Sprague-Dawley大鼠[1]剂量：20µg给药：脑室注射结果：大脑同一部位的血清素水平增加,而单胺氧化酶活性没有改变。

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
351.6±32.0 °C at 760 mmHg

[ 熔点 ]:
206-208 °C(lit.)

[ 分子式 ]:
C₁₁H₁₂N₂

[ 分子量 ]:
172.226

[ 闪点 ]:
166.5±25.1 °C

[ 精确质量 ]:
172.100052

[ PSA ]:
27.82000

[ LogP ]:
1.33

[ 外观性状 ]:
黄褐色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.670

[ 储存条件 ]:
Refrigerator

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚合成路线

详细合成路线

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚上下游产品

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚上游产品

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚下游产品

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚文献

Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

J. Chromatogr. A. 1210(1) , 115-20, (2008)

A number of N,N-dialkylated tryptamines show psychoactive properties in man which resulted in a renewed interest in psychopharmacological research. Attempts to manufacture these derivatives are increa...

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

PLoS ONE 6(8) , e23694, (2011)

The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed a...

A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Eur. J. Med. Chem. 46 , 3237-49, (2011)

The in vivo anti-thrombotic activities of amino acid modified tetrahydro-β-carbolines depended upon the proximity of the side chain of the amino acid residue to the carboline-cycle. Based on this prox...

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