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度他雄胺

度他雄胺用途

Dutasteride (GG745)是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。

度他雄胺名称

[ CAS 号 ]:
164656-23-9

[ 中文名 ]:
度他雄胺

[ 英文名 ]:
Dutasteride

[英文别名 ]:

Avodart
Duagen
Dutasteride

度他雄胺生物活性

[ 描述 ]:

Dutasteride (GG745)是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 5 alpha还原酶

研究领域 >> 癌症

[参考文献]

[1]. Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58(2):130-44.

[2]. Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.

[3]. Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282(3):1496-502.

[4]. Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175(5):1657-62.

[5]. Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23.

[相关活性小分子]

非那雄胺 | 爱普列特 | CGP-53153

度他雄胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
620.3±55.0 °C at 760 mmHg

[ 熔点 ]:
242-250ºC

[ 分子式 ]:
C₂₇H₃₀F₆N₂O₂

[ 分子量 ]:
528.530

[ 闪点 ]:
329.0±31.5 °C

[ 精确质量 ]:
528.221130

[ PSA ]:
58.20000

[ LogP ]:
5.61

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
DMSO: soluble2mg/mL, clear

度他雄胺安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

度他雄胺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

度他雄胺文献

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro

J. Steroid Biochem. Mol. Biol. 144 Pt B , 436-44, (2014)

• Dutasteride and abiraterone were evaluated for inhibition of steroidogenesis. • Bypass mechanisms arise in the presence of abiraterone to form DHT. • Dutasteride inhibits T and DHT effectively in vi...

Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction.

Arch. Pharm. Res. 37(12) , 1570-7, (2014)

The objective of this study was to prepare and characterize dutasteride (a hydrophobic model drug) microcapsules using ethyl cellulose as a capsule shell polymer with different drug/polymer ratios of ...

Long term effectiveness on prescribing of two multifaceted educational interventions: results of two large scale randomized cluster trials.

PLoS ONE 9(10) , e109915, (2014)

Information on benefits and risks of drugs is a key element affecting doctors' prescribing decisions. Outreach visits promoting independent information have proved moderately effective in changing pre...

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度他雄胺

度他雄胺用途

度他雄胺名称

度他雄胺生物活性

度他雄胺物理化学性质

度他雄胺安全信息

度他雄胺海关

度他雄胺文献

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