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4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐用途

二氢溴化伊姆匹普是一种H3激动剂。二氢溴化Imepip可以减少皮层组胺的释放。二氢溴化伊姆匹普可用于神经系统疾病的研究[1]。

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐名称

[ CAS 号 ]:
164391-47-3

[ 中文名 ]:
4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐

[ 英文名 ]:
Immepip, Dihydrobromide

[中文别名 ]:

[英文别名 ]:

Immepip dihydrobromide
Immepip,Dihydrobromide

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐生物活性

[ 描述 ]:

二氢溴化伊姆匹普是一种H3激动剂。二氢溴化Imepip可以减少皮层组胺的释放。二氢溴化伊姆匹普可用于神经系统疾病的研究[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[体内研究]

二氢溴化伊姆匹普(腹腔注射；5 mg/kg、10 mg/kg)显著减少皮质组胺释放,且微弱地促进大鼠睡眠[1]。

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐物理化学性质

[ 沸点 ]:
430.2ºC at 760mmHg

[ 熔点 ]:
234-235 °C

[ 分子式 ]:
C₉H₁₇Br₂N₃

[ 分子量 ]:
327.05900

[ 闪点 ]:
214ºC

[ 精确质量 ]:
324.97900

[ PSA ]:
40.71000

[ LogP ]:
3.19680

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
6.32E-08mmHg at 25°C

[ 储存条件 ]:
2-8°C

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐文献

Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.

Microcirculation 22 , 237-48, (2015)

The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated ...

Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.

ACS Chem. Neurosci. 5(8) , 637-45, (2014)

High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve te...

Development of time-resolved fluorescent based [EU]-GTP binding assay for selection of human Histamine 3 receptor antagonists/inverse agonist: a potential target for Alzheimer's treatment.

Ann Neurosci 19 , 71-5, (2014)

The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic f...

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