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脱镁叶绿酸盐 A

脱镁叶绿酸盐 A用途

菲叶绿酸A是叶绿素降解途径中的一种中间产物,可作为光敏剂使用。菲叶绿苷A是一种具有抗肿瘤活性的淋巴血管激活剂[1]。

脱镁叶绿酸盐 A名称

[ CAS 号 ]:
15664-29-6

[ 中文名 ]:
脱镁叶绿酸盐 A

[ 英文名 ]:
Pheophorbide A

[中文别名 ]:

脱镁叶绿酸-A

[英文别名 ]:

EINECS 239-738-5
[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo
13-Epi-phaeophorbide-a
Pheophorbide A
Demagnesia chloric acid -a

脱镁叶绿酸盐 A生物活性

[ 描述 ]:

菲叶绿酸A是叶绿素降解途径中的一种中间产物,可作为光敏剂使用。菲叶绿苷A是一种具有抗肿瘤活性的淋巴血管激活剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Jihye Kim, et al. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664.

脱镁叶绿酸盐 A物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1019.0±65.0 °C at 760 mmHg

[ 熔点 ]:
191-195°C (lit.)

[ 分子式 ]:
C₃₅H₃₆N₄O₅

[ 分子量 ]:
592.68

[ 闪点 ]:
570.1±34.3 °C

[ 精确质量 ]:
592.268555

[ PSA ]:
136.97000

[ LogP ]:
6.76

[ 外观性状 ]:
蓝色至暗棕色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
20°C，惰性气体，避光

脱镁叶绿酸盐 A安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

脱镁叶绿酸盐 A文献

Antioxidant-photosensitizer dual-loaded polymeric micelles with controllable production of reactive oxygen species.

Int. J. Pharm. 471(1-2) , 339-48, (2014)

Poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL) micelles dually loaded with both pheophorbide a (PhA) as a photosensitizer and β-carotene (CAR) as a singlet oxygen ((1)O2) scavenger were design...

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

J. Pharm. Pharmacol. 67(2) , 170-7, (2015)

It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast can...

ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy.

Sci. Rep. 5 , 13298, (2015)

Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of ...

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