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6,6'-二硫二烟酸

6,6'-二硫二烟酸用途

6,6′-二硫脒次酸是一种含硫有机化合物,属于烟酸衍生物,可作为特异性巯基阻断剂[1]。

6,6'-二硫二烟酸名称

[ CAS 号 ]:
15658-35-2

[ 中文名 ]:
6,6ˊ-二硫二烟酸

[ 英文名 ]:
3-Pyridinecarboxylicacid, 6,6'-dithiobis-

[中文别名 ]:

[英文别名 ]:

MFCD00006454
6,6'-Dithiobis(3-pyridinecarboxylic Acid)
EINECS 239-729-6
6,6'-Dithiodinicotinic Acid

6,6'-二硫二烟酸生物活性

[ 描述 ]:

6,6′-二硫脒次酸是一种含硫有机化合物,属于烟酸衍生物,可作为特异性巯基阻断剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Samir Abou-Khalil, et al. Effects of 6,6′-dithiodinicotinic acid, a thiol reagent on several mitochondrial functions: Coupling mechanism, ATPase and anion transport.Biochemical Pharmacology.Volume 24, Issue 1, 1 January 1975, Pages 49-56.

6,6'-二硫二烟酸物理化学性质

[ 密度 ]:
1.66g/cm3

[ 沸点 ]:
584.2ºC at 760mmHg

[ 熔点 ]:
263-265 °C(lit.)

[ 分子式 ]:
C₁₂H₈N₂O₄S₂

[ 分子量 ]:
308.33

[ 闪点 ]:
307.1ºC

[ 精确质量 ]:
307.99300

[ PSA ]:
150.98000

[ LogP ]:
2.67240

[ 外观性状 ]:
黄褐色粉末

[ 蒸汽压 ]:
1.71E-14mmHg at 25°C

[ 折射率 ]:
1.753

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

6,6'-二硫二烟酸MSDS

详细MSDS(安全技术说明书)

6,6'-二硫二烟酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5684700

CHEMICAL NAME :: 3-Pyridinecarboxylic acid, 6,6'-dithiobis-

CAS REGISTRY NUMBER :: 15658-35-2

BEILSTEIN REFERENCE NO. :: 0426589

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H8-N2-O4-S2

MOLECULAR WEIGHT :: 308.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,559,1986

6,6'-二硫二烟酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
US5684700

[ 海关编码 ]:
2933399090

6,6'-二硫二烟酸上下游产品

6,6'-二硫二烟酸上游产品

6,6'-二硫二烟酸下游产品

6,6'-二硫二烟酸海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6,6'-二硫二烟酸文献

Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).

Chemioterapia 5(4) , 219-27, (1986)

We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo h...

Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid.

Anal. Biochem. 138(1) , 95-8, (1984)

A simple and rapid method for the determination of nanomole levels of biological thiols is described. The analysis is based on the combination of reverse-phase high-performance liquid chromatography w...

Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system.

Biochem. J. 213(3) , 587-94, (1983)

The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gast...

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