磷酸安他唑啉

磷酸安他唑啉用途

Antazoline phosphate is an antihistamine with anticholinergic properties used to relieve nasal congestion and the symptoms of allergic conjunctivitis. Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles.

磷酸安他唑啉名称

[ CAS 号 ]:
154-68-7

[ 中文名 ]:
N-苄基-4,5-二氢-N-苯基-1H-咪唑-2-甲胺磷酸盐

[ 英文名 ]:
Antazoline

[中文别名 ]:

[英文别名 ]:

Antazoline Phosphate
Antazoline phosphate (USP)
UNII-VPR5FPH326
EINECS 205-831-4
MFCD00054317
Antazoline phosphate salt
2-(N-Benzylanilinomethyl)-2-imidazoline
2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE

磷酸安他唑啉物理化学性质

[ 密度 ]:
0.975 g/mL at 25 °C(lit.)

[ 沸点 ]:
235-236 °C(lit.)

[ 熔点 ]:
120-122ºC

[ 分子式 ]:
C₁₇H₂₂N₃O₄P

[ 分子量 ]:
363.348

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
363.134796

[ PSA ]:
115.20000

[ LogP ]:
1.53070

[ 蒸汽压 ]:
3.31E-09mmHg at 25°C

[ 折射率 ]:
n20/D 1.517(lit.)

磷酸安他唑啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

磷酸安他唑啉文献

Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Eur. J. Ophthalmol. 20(5) , 811-8, (2010)

To compare the effects of topical antiallergic eyedrops in relieving the signs and symptoms of patients with allergic conjunctival pathology.In this multicenter, single-masked, randomized study, 240 p...

Simultaneous determination of antazoline and naphazoline by the net analyte signal standard addition method and spectrophotometric technique.

J. AOAC Int. 93(6) , 1995-2001, (2010)

A novel net analyte signal standard addition method (NASSAM) was used for simultaneous determination of the drugs anthazoline and naphazoline. The NASSAM can be applied for determination of analytes i...

Determination of antihistamines based on the formation of mixed aggregates with surfactants.

Analyst 123(5) , 1079-84, (1998)

The determination of antihistamines based on the measurement of the critical micelle concentration (c.m.c.) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassi...

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