<生产厂家价格>

盐酸非索非那定

盐酸非索非那定用途

Fexofenadine是第三代抗组胺药,用于治疗过敏症状,如花粉热,鼻塞和荨麻疹。

盐酸非索非那定名称

[ CAS 号 ]:
153439-40-8

[ 中文名 ]:
盐酸非索非那定

[ 英文名 ]:
Fexofenadine hydrochloride

[中文别名 ]:

非索非那定盐酸盐

[英文别名 ]:

Fexofenadine HCl
Fexofenadine hydrochloride
MFCD08064193
UNII:2S068B75ZU
Fexofenadine (hydrochloride)

盐酸非索非那定生物活性

[ 描述 ]:

Fexofenadine是第三代抗组胺药,用于治疗过敏症状,如花粉热,鼻塞和荨麻疹。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Bachert C, et al. A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 31 (5): 921-44.

[2]. Compalati E, et al. Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.". International Archives of Allergy and Immunology 156 (1): 1-15.

[相关活性小分子]

盐酸非索非那定物理化学性质

[ 熔点 ]:
148-150oC

[ 分子式 ]:
C₃₂H₄₀ClNO₄

[ 分子量 ]:
538.117

[ 精确质量 ]:
537.264587

[ PSA ]:
81.00000

[ LogP ]:
6.25040

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
可溶于：甲醇

盐酸非索非那定安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

盐酸非索非那定文献

Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.

Biochem. Biophys. Res. Commun. 463 , 434-9, (2015)

Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan...

Probiotic properties of lactic acid bacteria isolated from water-buffalo mozzarella cheese.

Probiotics Antimicrob Proteins 6 , 141-56, (2014)

This study evaluated the probiotic properties (stability at different pH values and bile salt concentration, auto-aggregation and co-aggregation, survival in the presence of antibiotics and commercial...

Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.

Pharm. Res. 31(8) , 2035-43, (2014)

OATP2B1-mediated grapefruit juice (GFJ)-drug interactions are substrate-dependent; for example, GFJ ingestion significantly reduces bioavailability of fexofenadine, but not pravastatin. In the present...

更多文献