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3-氨基丙腈

3-氨基丙腈用途

β-Aminopropionitrile 是一种特异的不可逆赖氨酰氧化酶 (LOX) 抑制剂。β-Aminopropionitrile 靶向 LOX 或 LOXL 同工酶的活性位点。

3-氨基丙腈名称

[ CAS 号 ]:
151-18-8

[ 中文名 ]:
3-氨基丙腈

[ 英文名 ]:
Z2CN

[中文别名 ]:

[英文别名 ]:

3-Amino-1-propanethiolHCl
Propanenitrile, 3-amino-
chlorhydrate de mercapto-3 propylamine
3-amino-propionitrile
3-mercapto-1-propylamino hydrochloride
3-Aminopropionitrile
3-Mercaptopropylamine hydrochloride
EINECS 205-786-0
MFCD00014820
Z2CN

3-氨基丙腈生物活性

[ 描述 ]:

β-Aminopropionitrile 是一种特异的不可逆赖氨酰氧化酶 (LOX) 抑制剂。β-Aminopropionitrile 靶向 LOX 或 LOXL 同工酶的活性位点。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 神经信号通路 >> 单胺氧化酶

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

β-氨基丙腈阻断缺氧诱导的子宫颈癌细胞EMT形态和标志蛋白的变化,抑制宫颈癌细胞的侵袭和迁移能力[2]。

[参考文献]

[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.

[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.

3-氨基丙腈物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
186.3±13.0 °C at 760 mmHg

[ 分子式 ]:
C₃H₆N₂

[ 分子量 ]:
70.093

[ 闪点 ]:
66.5±19.8 °C

[ 精确质量 ]:
70.053101

[ PSA ]:
49.81000

[ LogP ]:
-1.02

[ 外观性状 ]:
透明无色至黄色液体

[ 蒸汽压 ]:
0.7±0.4 mmHg at 25°C

[ 折射率 ]:
1.430

[ 储存条件 ]:
库房通风低温干燥

3-氨基丙腈MSDS

详细MSDS(安全技术说明书)

3-氨基丙腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG0350000

CHEMICAL NAME :: Propionitrile, 3-amino-

CAS REGISTRY NUMBER :: 151-18-8

BEILSTEIN REFERENCE NO. :: 1698848

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H6-N2

MOLECULAR WEIGHT :: 70.11

WISWESSER LINE NOTATION :: Z2CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1152 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/11D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 14-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1250 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 1250 mg/kg

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981

3-氨基丙腈安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
3276

[ RTECS号 ]:
UG0350000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2926909090

3-氨基丙腈合成路线

详细合成路线

3-氨基丙腈制备

由丙烯腈经胺化而得。将干燥的高压釜冷至35℃以下，依次加入丙烯腈、二苯胺、叔丁醇，搅拌5min，加入液氨，温度控制在100-109℃，压力在1MPa左右，保温搅拌4h。冷至10℃以下，压力降至常压时停止搅拌。于65-70℃（14.7-21.3kPa）减压回收叔丁醇，得粗品3-氨基丙腈，粗品再减压蒸馏，收集66-105℃（1.33-4.0kPa）馏分，得3-氨基丙腈。

3-氨基丙腈海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%