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盐酸右美托咪啶

盐酸右美托咪啶用途

Dexmedetomidine盐酸盐是α2肾上腺素受体激动剂,有止痛镇静活性。

盐酸右美托咪啶名称

[ CAS 号 ]:
145108-58-3

[ 中文名 ]:
盐酸右美托咪定

[ 英文名 ]:
Dexmedetomidine hydrochloride

[中文别名 ]:

[英文别名 ]:

Dexdor
MFCD07772269
UNII:BH210P244U
UNII-1018WH7F9I
Precedex
Dexmedetomidine HCL
Dexmedetomidine Hydrochloride
Dexmedetomidine HCl
Dexmedetomidine (hydrochloride)

盐酸右美托咪啶生物活性

[ 描述 ]:

Dexmedetomidine盐酸盐是α2肾上腺素受体激动剂,有止痛镇静活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

信号通路 >> 自噬 >> 自噬

研究领域 >> 神经疾病

[参考文献]

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

[相关活性小分子]

盐酸右美托咪啶物理化学性质

[ 沸点 ]:
381.9ºC at 760 mmHg

[ 熔点 ]:
153 - 158ºC

[ 分子式 ]:
C₁₃H₁₇ClN₂

[ 分子量 ]:
236.740

[ 精确质量 ]:
236.108032

[ PSA ]:
28.68000

[ LogP ]:
3.98030

[ 蒸汽压 ]:
1.08E-05mmHg at 25°C

[ 储存条件 ]:
Desiccate at RT

盐酸右美托咪啶MSDS

详细MSDS(安全技术说明书)

盐酸右美托咪啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NI5156750

盐酸右美托咪啶文献

Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers.

Vet. Ophthalmol. 18 , 364-70, (2015)

To determine whether dogs with spontaneous chronic corneal epithelial defects (SCCEDs) would heal faster and with an improved comfort score following linear grid keratotomy (LGK) combined with corneal...

Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.

Mol. Psychiatry 19(7) , 823-33, (2014)

3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensiv...

Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.

Electrophoresis 36 , 1349-57, (2015)

Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of can...

更多文献

盐酸右美托咪啶

盐酸右美托咪啶用途

盐酸右美托咪啶名称

盐酸右美托咪啶生物活性

盐酸右美托咪啶物理化学性质

盐酸右美托咪啶MSDS

详细MSDS(安全技术说明书)

盐酸右美托咪啶安全信息

盐酸右美托咪啶文献

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