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甲磺酸依普罗沙坦

甲磺酸依普罗沙坦用途

Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。

甲磺酸依普罗沙坦名称

[ CAS 号 ]:
144143-96-4

[ 中文名 ]:
甲磺酸依普罗沙坦

[ 英文名 ]:
Eprosartan mesylate

[中文别名 ]:

莱克多巴胺

[英文别名 ]:

MFCD08141807
Eprosartan mesylate
Eprosartan (mesylate)

甲磺酸依普罗沙坦生物活性

[ 描述 ]:

Eprosartan是非肽类血管紧张素II受体拮抗剂,在鼠和人肾上腺皮质膜中的IC50分别为9.2和3.9 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

研究领域 >> 心血管疾病

[参考文献]

[1]. Qian, J.J., et al., Eprosartan mesylate, an angiotensin II receptor antagonist. Acta Crystallogr Sect E Struct Rep Online, 2011. 67(Pt 4): p. o770-1.

[2]. Edwards, R.M., et al., Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther, 1992. 260(1): p. 175-81.

[3]. Conter, H.S., D.W. McKay, and R.J. Reiz, Eprosartan mesylate effectively reduces systolic and diastolic blood pressure in a Canadian primary care setting. Can J Cardiol, 2004. 20 Suppl C: p. 6C-10C.

[4]. Punzi, H.A. and C.F. Punzi, Once-daily eprosartan mesylate in the treatment of elderly patients with isolated systolic hypertension: data from a 13-week double-blind, placebo-controlled, parallel, multicenter study. J Hum Hypertens, 2004. 18(9): p. 655-61

[5]. Martynov, M., et al., [Eprosartan mesylate in controlling of blood pressure in patients with ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova, 2002. 102(4): p. 26-30.

[相关活性小分子]

甲磺酸依普罗沙坦物理化学性质

[ 密度 ]:
1.26 g/cm3

[ 沸点 ]:
660.6ºC

[ 熔点 ]:
248 °C

[ 分子式 ]:
C₂₄H₂₈N₂O₇S₂

[ 分子量 ]:
520.618

[ 闪点 ]:
353.3ºC

[ 精确质量 ]:
520.133789

[ PSA ]:
183.41000

[ LogP ]:
5.32920

[ 外观性状 ]:
一种白色至灰白色粉末

[ 蒸汽压 ]:
2.37E-18mmHg at 25°C

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
水溶性：不溶；易溶于：乙醇

甲磺酸依普罗沙坦安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

甲磺酸依普罗沙坦海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甲磺酸依普罗沙坦文献

Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays.

BMC Immunol. 10 , 52, (2009)

Growing knowledge about cellular interactions in the immune system, including the central role of cytokine networks, has lead to new treatments using monoclonal antibodies that block specific componen...

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