(+/-)-4-羟基普萘洛尔盐酸盐

(+/-)-4-羟基普萘洛尔盐酸盐用途

4-Hydroxypropranolol hydrochloride 是 Propranolol 的活性代谢产物。4-Hydroxypropranolol hydrochloride 的效力与 Propranolol 相当。4-Hydroxypropranolol hydrochloride 抑制 β1-和 β2-肾上腺素能受体,pA2 值分别为 8.24 和 8.26。4-Hydroxypropranolol hydrochloride 具有固有的拟交感活性,膜稳定活性和强效的抗氧化性能。

(+/-)-4-羟基普萘洛尔盐酸盐名称

[ CAS 号 ]:
14133-90-5

[ 中文名 ]:
4-羟普萘洛尔

[ 英文名 ]:
4-hydroxy propranolol hcl

[中文别名 ]:

4-羟普萘洛尔盐酸盐

[英文别名 ]:

4-hydroxy propranolol hcl

(+/-)-4-羟基普萘洛尔盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

[ 靶点 ]

pA2: 8.24 (β1-adrenergic receptor) and 8.26 (β2-adrenergic receptor)[2]

[参考文献]

[1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35.

[2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61.

[3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.

(+/-)-4-羟基普萘洛尔盐酸盐物理化学性质

[ 密度 ]:
1.168g/cm3

[ 沸点 ]:
487.5ºC at 760mmHg

[ 熔点 ]:
156-158ºC

[ 分子式 ]:
C₁₆H₂₂ClNO₃

[ 分子量 ]:
311.804

[ 闪点 ]:
248.6ºC

[ 精确质量 ]:
311.128815

[ PSA ]:
61.72000

[ LogP ]:
3.47600

[ 储存条件 ]:
2-8°C

(+/-)-4-羟基普萘洛尔盐酸盐MSDS

详细MSDS(安全技术说明书)

(+/-)-4-羟基普萘洛尔盐酸盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2922509090

(+/-)-4-羟基普萘洛尔盐酸盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(+/-)-4-羟基普萘洛尔盐酸盐文献

Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.

J. Chromatogr. B. Biomed. Sci. Appl. 692(1) , 133-40, (1997)

A stereoselective reversed-phase HPLC assay to quantify S-(-) and R-(+) enantiomers of propranolol and 4-hydroxypropranolol in human plasma was developed. The method involved liquid-liquid extraction ...

Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC–MS/MS quantitation of metabolites

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(31) , 3267-76, (2010)

In recent years, increasing emphasis has been placed on quantitative characterization of drug metabolites for better insight into the correlation between metabolite exposure and toxicological observat...

Potent antioxidant properties of 4-hydroxyl-propranolol.

J. Pharmacol. Exp. Ther. 308(1) , 85-90, (2004)

The antioxidant properties of 4-HO-propranolol (4HOP), a major metabolite of propranolol, were studied and compared with that of propranolol and vitamin E (Trolox). When isolated hepatic microsomal me...

更多文献