寡霉素
寡霉素用途
寡霉素名称
[ CAS 号 ]:
1404-19-9
[ 中文名 ]:
寡霉素
[ 英文名 ]:
Oligomycin
[英文别名 ]:
- Oligomycin From Streptomyces Diastatochromogenes
- EINECS 215-767-9
- MFCD00065705
寡霉素生物活性
寡霉素物理化学性质
[ 密度 ]:
1.14 g/cm3
[ 沸点 ]:
886.3ºC at 760 mmHg
[ 熔点 ]:
84-100ºC
[ 分子式 ]:
C135H220O33
[ 分子量 ]:
2371.171
[ 闪点 ]:
252ºC
[ 精确质量 ]:
2369.553711
[ PSA ]:
536.99000
[ LogP ]:
17.71190
[ 外观性状 ]:
灰白色至白色粉末
[ 蒸汽压 ]:
0mmHg at 25°C
[ 折射率 ]:
1.543
[ 储存条件 ]:
−20°C
[ 水溶解性 ]:
Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
寡霉素MSDS
寡霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RK3325000
- CHEMICAL NAME :
- Oligomycin
- CAS REGISTRY NUMBER :
- 1404-19-9
- LAST UPDATED :
- 199012
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 15,660,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954
寡霉素安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301
[ 警示性声明 ]:
P301 + P310
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
24/25
[ 危险品运输编码 ]:
UN 2811
[ WGK德国 ]:
3
[ RTECS号 ]:
RK3325000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
寡霉素文献
Mol. Endocrinol. 29(1) , 130-9, (2014)
Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 d...
Mitochondrial function provides instructive signals for activation-induced B-cell fates.Nat. Commun. 6 , 6750, (2015)
During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we...
Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.Sci. Rep. 5 , 16895, (2015)
Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) regulates cha...
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相关化合物
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标题:寡霉素_MSDS_用途_密度_寡霉素CAS号【1404-19-9】_化源网 地址:https://www.chemsrc.com/amp/cas/1404-19-9_964807.html