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奈喹酯

奈喹酯用途

【用途一】
用作饲料添加剂。

奈喹酯名称

[ CAS 号 ]:
13997-19-8

[ 中文名 ]:
甲氧苄喹酯

[ 英文名 ]:
Nequinate

[中文别名 ]:

[英文别名 ]:

nequinate
MFCD00867198
EINECS 237-796-6

奈喹酯生物活性

[ 描述 ]:

Nequinate 是一种喹啉化合物,抗球虫试剂 (anticoccidial agent),对抗盲肠球虫 (Eimeria tenella) 感染。Nequinate 抑制黄嘌呤氧化还原酶 (XOD) 活性。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 代谢疾病

信号通路 >> 代谢酶/蛋白酶 >> 黄嘌呤氧化酶

[体外研究]

黄嘌呤氧化酶(XOD)是一种安全有效的降低血清尿酸盐(sUA)水平的药物靶点,在嘌呤奈奎酸的分解代谢中起重要作用,抑制XOD活性的抑制率为12.0%。

[参考文献]

[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21.

[2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.

奈喹酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
520.7±50.0 °C at 760 mmHg

[ 熔点 ]:
287.5ºC

[ 分子式 ]:
C₂₂H₂₃NO₄

[ 分子量 ]:
365.422

[ 闪点 ]:
268.7±30.1 °C

[ 精确质量 ]:
365.162720

[ PSA ]:
68.39000

[ LogP ]:
6.01

[ 外观性状 ]:
淡黄色,无气味的粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.579

奈喹酯MSDS

详细MSDS(安全技术说明书)

奈喹酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H413

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933499090

奈喹酯海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

奈喹酯文献

Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.

Vet. Parasitol. 76(3) , 163-71, (1998)

Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC...

Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.

Res. Vet. Sci. 47(1) , 125-8, (1989)

Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl ben...

Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field.

Res. Vet. Sci. 35(2) , 211-6, (1983)

For 15 months the anticoccidial effect of 200 ppm clopidol/methyl benzoquate and of 50 ppm robenidine, and the development of immunity against five different species of Eimeria were followed in a clos...

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奈喹酯