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瑞格列奈

瑞格列奈用途

Repaglinide(AG-EE 623ZW)是氨基甲酰甲基苯甲酸(CMBA)衍生物,可作用于II型糖尿病。

瑞格列奈名称

[ CAS 号 ]:
135062-02-1

[ 中文名 ]:
瑞格列奈

[ 英文名 ]:
Repaglinide

[中文别名 ]:

瑞格列萘

[英文别名 ]:

Repaglinid
AG EE-623 ZW
MFCD00906179
Prandin,GlucoNorm,NovoNorm
Repaglinide

瑞格列奈生物活性

[ 描述 ]:

Repaglinide(AG-EE 623ZW)是氨基甲酰甲基苯甲酸(CMBA)衍生物,可作用于II型糖尿病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Marbury T, Huang WC, Strange P, Lebovitz H et al. Repaglinide versus glyburide: a one-year comparison trial. Diabetes Research and Clinical Practice .1999, 43(3):155-166.

[2]. David R. Owens . Repaglinide-prandial glucose regulator: a new class of oral antidiabetic drugs . Diabetic Medicine 1998,15 : S28-S36.

[3]. J Fuhlendorff, P Rorsman, H Kofod. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 1998. 47 (3): 345-351 .

[4]. R Moses, R Slobodniuk, S Boyages. Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care . 22 (1 ) : 119-124 .

[5]. Julio Rosenstock, MD, David R. Hassman, DO, Robert D. Madder, DO. Diabetes Care June 2004 vol. 27 no. 6 1265-1270

[6]. Shiling Hu1, Shuya Wang1, Barbara Fanelli1. Pancreatic β-Cell KATP Channel Activity and Membrane-Binding Studies with Nateglinide: A Comparison with Sulfonylureas and Repaglinide . JPET , 2000,293 (2 ): 444-452 .

[相关活性小分子]

瑞格列奈物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
672.9±55.0 °C at 760 mmHg

[ 熔点 ]:
129-130.2 °C

[ 分子式 ]:
C₂₇H₃₆N₂O₄

[ 分子量 ]:
452.586

[ 闪点 ]:
360.8±31.5 °C

[ 精确质量 ]:
452.267517

[ PSA ]:
78.87000

[ LogP ]:
4.69

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: 34 mg/mL

瑞格列奈MSDS

瑞格列奈安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
000000033825

[ 海关编码 ]:
2933399090

瑞格列奈合成路线

瑞格列奈上下游产品

瑞格列奈上游产品

瑞格列奈下游产品

瑞格列奈制备

3-甲基-1-[2-(1-哌啶)苯基]丁胺转化为N-乙酰基衍生物后，再通过和L-谷氨酸成盐拆分得到(S)型的旋光异构体，然后和3-乙氧基-4-乙氧羰基苯乙酸进行酰化反应形成酰胺，再水解得到产物。

瑞格列奈海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

瑞格列奈文献

[symbol: see text] Nateglinide and [symbol: see text] repaglinide for type 2 diabetes?

Drug Ther. Bull. 41(7) , 52-4, (2003)

[symbol: see text] Nateglinide (Starlix-Novartis) and [symbol: see text] repaglinide (NovoNorm-Novo Nordisk) are two of a new class of orally active antidiabetic drugs, the meglitinides. They have a r...

Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide.

Clin. Pharmacokinet. 46(2) , 93-108, (2007)

This review describes the current knowledge on drug-drug and food-drug interactions with repaglinide and nateglinide. These two meglitinide derivatives, commonly called glinides, have been developed f...

Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.

Drug Metab. Dispos. 41(2) , 362-71, (2013)

The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based...

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