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5,8,11-十二烯酸

5,8,11-十二烯酸用途

5,8,11-二十碳三烯酸(ETI)是一种脂氧合酶抑制剂,可阻断肥大细胞肿瘤细胞中LTC4的生物合成[1]。

5,8,11-十二烯酸名称

[ CAS 号 ]:
13488-22-7

[ 中文名 ]:
5,8,11-十二烯酸

[ 英文名 ]:
ETI

[英文别名 ]:

Icosa-5,8,11-triynoic acid
MFCD00077343
5,8,11-Eicosatriynoic acid
5,8,11-Icosatriynoic acid

5,8,11-十二烯酸生物活性

[ 描述 ]:

5,8,11-二十碳三烯酸(ETI)是一种脂氧合酶抑制剂,可阻断肥大细胞肿瘤细胞中LTC4的生物合成[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. L Orning, et al. Inhibition of leukotriene C and leukotriene D biosynthesis. J Biol Chem. 1980 Sep 10;255(17):8023-6.

5,8,11-十二烯酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
473.8±40.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₈O₂

[ 分子量 ]:
300.44

[ 闪点 ]:
221.9±22.0 °C

[ 精确质量 ]:
300.208923

[ PSA ]:
37.30000

[ LogP ]:
6.15

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.507

5,8,11-十二烯酸MSDS

5,8,11-十二烯酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2916190090

5,8,11-十二烯酸合成路线

5,8,11-十二烯酸上下游产品

5,8,11-十二烯酸上游产品

5,8,11-十二烯酸下游产品

5,8,11-十二烯酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

5,8,11-十二烯酸文献

Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells.

Biochim. Biophys. Acta 1401(3) , 277-88, (1998)

Nonsteroidal anti-inflammatory drugs (NSAIDs) and short-chain fatty acids are effective suppressors of colorectal cancer that may work in part by accentuating apoptosis of transformed cells. Since rea...

Eicosatetraynoic and arachidonic acid-induced changes in cell membrane fluidity consonant with differences in computer-aided design-structures.

Biochim. Biophys. Acta 1105(2) , 285-90, (1992)

ETYA (5,8,11,14-eicosatetraynoic acid), a competitive analogue of arachidonic acid (AA), inhibits the proliferation of U937 (human monoblastoid) and PC3 (human prostate) cancer cells, without the over...

Chlamydia pneumoniae induces nitric oxide synthase and lipoxygenase-dependent production of reactive oxygen species in platelets. Effects on oxidation of low density lipoproteins.

Thromb. Haemost. 94(2) , 327-35, (2005)

There is increasing evidence that Chlamydia pneumoniae is linked to atherosclerosis and thrombosis. In this regard, we have recently shown that C. pneumoniae stimulates platelet aggregation and secret...

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