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前列腺素 B2

前列腺素 B2用途

前列腺素B2是一种前列腺素。前列腺素B2是脐血间充质干细胞中的主要物质,能抑制DC-T细胞的增殖。前列腺素B2还诱导犬后爪的皮肤血管收缩[1][2]。

前列腺素 B2名称

[ CAS 号 ]:
13367-85-6

[ 中文名 ]:
前列腺素 B2

[ 英文名 ]:
Prostaglandin B2

[英文别名 ]:

MFCD00065730
EINECS 234-237-8
Prostaglandin B2

前列腺素 B2生物活性

[ 描述 ]:

前列腺素B2是一种前列腺素。前列腺素B2是脐血间充质干细胞中的主要物质,能抑制DC-T细胞的增殖。前列腺素B2还诱导犬后爪的皮肤血管收缩[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Greenberg S, Engelbrecht JA, Wilson WR. Prostaglandin B2-induced cutaneous vasoconstriction of the canine hind paw. Circ Res. 1974 Apr;34(4):491-7.

[2]. van den Berk LC, et al. Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2. Stem Cells Dev. 2014 Jul 15;23(14):1582-93.

前列腺素 B2物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
537.0±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₀O₄

[ 分子量 ]:
334.45

[ 闪点 ]:
292.6±26.6 °C

[ 精确质量 ]:
334.214417

[ PSA ]:
74.60000

[ LogP ]:
3.24

[ 外观性状 ]:
solution

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
ethanol: ~100 mg/mL

前列腺素 B2安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn,Xi,F

[ 风险声明 (欧洲) ]:
20/21/22-67-66-36-11

[ 安全声明 (欧洲) ]:
36/37-26

[ 危险品运输编码 ]:
UN 1231 3/PG 2

[ WGK德国 ]:
3

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前列腺素 B2文献

Identification of prostamides, fatty acyl ethanolamines, and their biosynthetic precursors in rabbit cornea.

J. Lipid Res. 56 , 1419-33, (2015)

Arachidonoyl ethanolamine (anandamide) and pros-taglandin ethanolamines (prostamides) are biologically active derivatives of arachidonic acid. Although available through different precursor phospholip...

Differences in the Neuroprotective Effect of Orally Administered Virgin Olive Oil (Olea europaea) Polyphenols Tyrosol and Hydroxytyrosol in Rats.

J. Agric. Food Chem. 63 , 5957-63, (2015)

The neuroprotective effect of virgin olive oil (VOO) polyphenols has been related to their antioxidant effect. The main objective was to analyze how tyrosol and hydroxytyrosol contribute to the antiox...

Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.

Stem Cells Dev. 23(14) , 1582-93, (2014)

Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long cul...

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