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PGB1(前列腺素B1)

PGB1(前列腺素B1)用途

Prostaglandin B1 (PGB1) 是 Prostaglandin E1 (HY-B0131) 的代谢产物。Prostaglandin E1 是一种前列腺素受体配体。

PGB1(前列腺素B1)名称

[ CAS 号 ]:
13345-51-2

[ 中文名 ]:
前列腺素B1

[ 英文名 ]:
Prostaglandin B1

[中文别名 ]:

前列腺素 B1

[英文别名 ]:

Prostaglandin B1
EINECS 234-237-8
MFCD00036679

PGB1(前列腺素B1)生物活性

[ 描述 ]:

Prostaglandin B1 (PGB1) 是 Prostaglandin E1 (HY-B0131) 的代谢产物。Prostaglandin E1 是一种前列腺素受体配体。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[参考文献]

[1]. Bygdeman M, et, al. The effect of eight new prostaglandins on human myometrium. Acta Physiol Scand. 1967 Apr;69(4):320-6.

[2]. Zoutendam PH, et, al. Quantitative determination of prostaglandins A1 and B1 in alprostadil (PGE1) by high-performance liquid chromatography. J Chromatogr. 1984 Jan 20;283:281-7.

PGB1(前列腺素B1)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
531.4±43.0 °C at 760 mmHg

[ 熔点 ]:
69-71°C(lit.)

[ 分子式 ]:
C₂₀H₃₂O₄

[ 分子量 ]:
336.47

[ 闪点 ]:
289.2±24.7 °C

[ 精确质量 ]:
336.230072

[ PSA ]:
74.60000

[ LogP ]:
3.56

[ 外观性状 ]:
powder | white to light yellow

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
acetone: 20 mg/mL, clear, colorless to very faintly yellow

PGB1(前列腺素B1)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918990090

PGB1(前列腺素B1)海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

PGB1(前列腺素B1)文献

NADP(+)-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification.

Free Radic. Biol. Med. 83 , 66-76, (2015)

An NADP(+)-dependent dehydrogenase activity on 3-glutathionyl-4-hydroxynonanal (GSHNE) was purified to electrophoretic homogeneity from a line of human astrocytoma cells (ADF). Proteomic analysis iden...

A novel synthesis of racemic and enantiomeric forms of prostaglandin B1 methyl ester.

J. Org. Chem. 65(17) , 5127-30, (2000)

3-(Dimethoxyphosphorylmethyl)cyclopent-2-enone was converted into (+/-)-prostaglandin B1 methyl ester in two steps involving regioselective alkylation at C(2) with methyl 7-iodoheptanoate and subseque...

Prostaglandin B1 can modify the pressor responses to sympathetic nerve stimulation.

Res. Commun. Chem. Pathol. Pharmacol. 41(3) , 397-405, (1983)

PGB1, a metabolite of PGA1, has the ability to enhance peripheral vascular resistance and elevate blood pressure in animals whose vascular tone is low. The effect is not central in origin and apparent...

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