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硫酸氯喹

硫酸氯喹用途

用作抗疟药。

硫酸氯喹名称

[ CAS 号 ]:
132-73-0

[ 中文名 ]:
硫酸氯喹

[ 英文名 ]:
chloroquine sulphate

[英文别名 ]:

Cisplaquin
Chloroquin sulfate
Lariago
Chloroquine sulphate
Chloroquine sulfate
EINECS 205-077-6
UNII:OE48649K6N
Chlorquine sulfate
Ciplaquin
Nivaquine

硫酸氯喹物理化学性质

[ 密度 ]:
0.773 g/mL at 25 °C(lit.)

[ 沸点 ]:
84-86 °C35 mm Hg(lit.)

[ 分子式 ]:
C₁₈H₂₈ClN₃O₄S

[ 分子量 ]:
417.951

[ 闪点 ]:
99 °F

[ 精确质量 ]:
417.148895

[ PSA ]:
111.14000

[ LogP ]:
5.31160

[ 蒸汽压 ]:
1.15E-08mmHg at 25°C

[ 折射率 ]:
n20/D 1.434(lit.)

硫酸氯喹毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB2635000

CAS REGISTRY NUMBER :: 132-73-0

LAST UPDATED :: 199112

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H26-Cl-N3.H2-O4-S

MOLECULAR WEIGHT :: 418.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 154 mg/kg/11W-I

TOXIC EFFECTS :: Skin and Appendages - hair

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - coma Cardiac - cardiomyopathy including infarction

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 5 mg/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,311,1989

硫酸氯喹安全信息

[ 危险品运输编码 ]:
1544

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)