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(+/-)-SGCBD01, [(R,S)-4-(4-氯苯基)-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯, N-(2′,5′-二甲氧基 [1,1'-联苯 ]-4-基)-3-氟-4-吡啶甲酰胺

名称

[ CAS 号 ]:
1268524-69-1

[ 中文名 ]:
(+/-)-SGCBD01, [(R,S)-4-(4-氯苯基)-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯, N-(2′,5′-二甲氧基 [1,1'-联苯 ]-4-基)-3-氟-4-吡啶甲酰胺

[ 英文名 ]:
(+/-)-JQ1

[英文别名 ]:

物理化学性质

[ 密度 ]:
1.33±0.1 g/cm3(Predicted)

[ 沸点 ]:
610.4±65.0 °C(Predicted)

[ 分子式 ]:
C23H25ClN4O2S

[ 分子量 ]:
456.98800

[ 精确质量 ]:
456.13900

[ PSA ]:
97.61000

[ LogP ]:
4.96690

[ 外观性状 ]:
powder,white to beige

[ 储存条件 ]:
室温

MSDS

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

合成路线

上下游产品

文献

Selective inhibition of BET bromodomains.

Nature 468(7327) , 1067-73, (2010)

Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Pote...

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

Nature 510(7504) , 278-82, (2014)

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated and...


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相关化合物

CAS号[1268524-69-1]化源网提供[(+/-)-SGCBD01, [(R,S)-4-(4-氯苯基)-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯, N-(2′,5′-二甲氧基 [1,1'-联苯 ]-4-基)-3-氟-4-吡啶甲酰胺]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:(+/-)-SGCBD01, [(R,S)-4-(4-氯苯基)-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯, N-(2′,5′-二甲氧基 [1,1'-联苯 ]-4-基)-3-氟-4-吡啶甲酰胺

标题:1268524-69-1_CAS号:1268524-69-1_(+/-)-SGCBD01, [(R,S)-4-(4-氯苯基)-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯, N-(2′,5′-二甲氧基 [1,1'-联苯 ]-4-基)-3-氟-4-吡啶甲酰胺 - 化源网 地址:https://www.chemsrc.com/amp/cas/1268524-69-1_435707.html