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5α,6α-epoxy Cholestanol

5α,6α-epoxy Cholestanol用途

胆固醇-5α,6α-环氧化物是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

5α,6α-epoxy Cholestanol名称

[ CAS 号 ]:
1250-95-9

[ 中文名 ]:
胆固醇-5Alpha,6Alpha-环氧化物

[ 英文名 ]:
Cholesterol-5α,6α-epoxide

[中文别名 ]:

胆固醇-5Α,6Α-环氧化物

[英文别名 ]:

Cholesterol epoxide
5,6alpha-epoxy-5alpha-cholestan-3beta-ol
Cholesterol-5α,6α-epoxide
MFCD00046980
Epoxycholesterol
cholestanol
EINECS 215-007-6
Cholesterol-5alpha,6alpha-epoxide

5α,6α-epoxy Cholestanol生物活性

[ 描述 ]:

胆固醇-5α,6α-环氧化物是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

5α,6α-epoxy Cholestanol物理化学性质

[ 密度 ]:
1.04g/cm3

[ 沸点 ]:
497.7ºC at 760mmHg

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.65300

[ 闪点 ]:
200.9ºC

[ 精确质量 ]:
402.35000

[ PSA ]:
32.76000

[ LogP ]:
6.59990

[ 蒸汽压 ]:
5.43E-12mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
室温

5α,6α-epoxy CholestanolMSDS

5α,6α-epoxy Cholestanol毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ6360000

CHEMICAL NAME :: 5-alpha-Cholestan-3-beta-ol, 5,6-alpha-epoxy-

CAS REGISTRY NUMBER :: 1250-95-9

BEILSTEIN REFERENCE NO. :: 0089511

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C27-H46-O2

MOLECULAR WEIGHT :: 402.73

WISWESSER LINE NOTATION :: T3 F5 E666 1A R AXO CH&TTTTJ IY1&3Y1&1 J1 QQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 25 umol/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1103,1986

5α,6α-epoxy Cholestanol安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
FZ6360000

5α,6α-epoxy Cholestanol合成路线

5α,6α-epoxy Cholestanol上下游产品

5α,6α-epoxy Cholestanol上游产品

5α,6α-epoxy Cholestanol下游产品

5α,6α-epoxy Cholestanol制备

1. 从5%丙酮/水溶液中结晶，得无色真晶。

5α,6α-epoxy Cholestanol文献

Oxysterols: modulators of cholesterol metabolism and other processes.

Physiol. Rev. 80 , 361-554, (2000)

Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and pro...

Oxysterols as non-genomic regulators of cholesterol homeostasis.

Trends Endocrinol. Metab. 23 , 99-106, (2012)

Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease...

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.

J. Lipid Res. 53(4) , 718-25, (2012)

We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the...

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