培拉嗪-d8 二盐酸盐

培拉嗪-d8是氘化形式的培拉嗪，一种人细胞色素P450同工酶1A2（CYP1A2）抑制剂。在人肝微粒体和CYP1A2中的狄克逊分析表明，培拉嗪可以有效抑制咖啡因3-N-去甲基化和1-N-去甲基化，并适度抑制咖啡因7-N-去甲基化。超体CYP1A2对C-8-羟基化的抑制作用减弱，而咖啡因对C-8-羟基化的抑制作用较弱。 Perazine-d8 is a deuterated form of Perazine , a human cytochrome P450 isoenzyme 1A2 (CYP1A2) inhibitor. Dixon analysis in human liver microsomes and Supersomes CYP1A2 showed Perazine acts as a potent inhibitor of caffeine 3-N-demethylation and 1-N-demethylation, as well as moderate inhibition of caffeine 7-N-demethylation. Attenuation of C-8-hydroxylation was seen in Supersomes CYP1A2, however, weak inhibition of caffeine C-8-hydroxylation was found.

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
493.6±40.0 °C at 760 mmHg

[ 熔点 ]:
191-199° C (dec.)

[ 分子式 ]:
C₂₀H₁₉D₈Cl₂N₃S

[ 分子量 ]:
420.47

[ 闪点 ]:
252.3±27.3 °C

[ 精确质量 ]:
347.227142

[ LogP ]:
4.04

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.616

[ 储存条件 ]:
-20°C储存

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1953.9/1mg ￥7209.9/5mg ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：培拉嗪-d8

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