2-氟-3,3-二甲基-2,3-二氢-1,2-苯并异噻唑 1,1-二氧化物

名称

[ CAS 号 ]:
124170-23-6

[ 中文名 ]:
2,3-二氢-3,3-二甲基-2-氟-1,2-苯并异噻唑 1,1-二氧化物

[ 英文名 ]:
2,3-DIHYDRO-3,3-DIMETHYL-2-FLUORO-1,2-BENZISOTHIAZOLE 1,1-DIOXIDE

[英文别名 ]:

N-Fluoro-2,|A-cumenesultam
N-fluorosultam

物理化学性质

[ 密度 ]:
1.41g/cm3

[ 沸点 ]:
307.6ºC at 760 mmHg

[ 熔点 ]:
115-117ºC

[ 分子式 ]:
C₉H₁₀FNO₂S

[ 分子量 ]:
215.24500

[ 闪点 ]:
139.9ºC

[ 精确质量 ]:
215.04200

[ PSA ]:
45.76000

[ LogP ]:
2.82920

[ 蒸汽压 ]:
0.000715mmHg at 25°C

[ 折射率 ]:
1.59

[ 储存条件 ]:
室温，干燥，密封，充气

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934991000

合成路线

详细合成路线

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海关

[ 海关编码 ]: 2934991000

[ 中文概述 ]:
2934991000. 磺内酯及磺内酰胺. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

文献

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.

J. Med. Chem. 54(1) , 78-94, (2011)

A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to af...

E. Differding et al.

Tetrahedron Lett. 32 , 1779, (1991)

E. Differding, M. Wehrli

Tetrahedron Lett. 32 , 3819, (1991)

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