ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER

用途

CRF(6-33)(human) 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂,与 CRF-BP 竞争性结合,但不与突触后 CRF 受体结合。CRF(6-33)(human) 具有抗肥胖作用。

名称

[ CAS 号 ]:
120066-38-8

[ 中文名 ]:
ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER

[ 英文名 ]:
CRF (6-33)

[英文别名 ]:

MFCD00671436

生物活性

[ 描述 ]:

CRF(6-33)(human) 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂,与 CRF-BP 竞争性结合,但不与突触后 CRF 受体结合。CRF(6-33)(human) 具有抗肥胖作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR

研究领域 >> 神经疾病

[参考文献]

[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50.

[2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

物理化学性质

[ 分子式 ]:
C₁₄₁H₂₃₁N₄₁O₄₃S

[ 分子量 ]:
3220.66000

[ 精确质量 ]:
3218.69000

[ PSA ]:
1394.64000

[ LogP ]:
3.96850

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C，密封，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

Mol. Psychiatry 1 , 265-277, (1996)

The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid pr...

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal.

Proc. Natl. Acad. Sci. U. S. A. 93 , 15475-15480, (1996)

Elevation of the neuropeptide corticotropin-releasing factor (CRF) in the brain is associated with a reduction of food intake and body weight gain in normal and obese animals. A protein that binds CRF...

更多文献