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四氯邻苯二酚

四氯邻苯二酚用途

Tetrachlorocatechol 是五氯酚的代谢产物。Tetrachlorocatechol 是纸浆氯漂过程中产生的一种毒性最大的氯代邻苯二酚,常见于硫酸盐制浆废水中。

四氯邻苯二酚名称

[ CAS 号 ]:
1198-55-6

[ 中文名 ]:
四氯邻苯二酚

[ 英文名 ]:
3,4,5,6-Tetrachlorobenzene-1,2-diol

[中文别名 ]:

[英文别名 ]:

1,2-Benzenediol, 3,4,5,6-tetrachloro-
MFCD00002190
3,4,5,6-Tetrachloro-1,2-benzenediol (9CI)
3,4,5,6-tetrachlorobenzene-1,2-diol
3,4,5,6-Tetrachloro-1,2-benzenediol
TETRACHLOROCATECHOL

四氯邻苯二酚生物活性

[ 描述 ]:

Tetrachlorocatechol 是五氯酚的代谢产物。Tetrachlorocatechol 是纸浆氯漂过程中产生的一种毒性最大的氯代邻苯二酚,常见于硫酸盐制浆废水中。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. G. Renner, et al. Acute toxicities of pentachlorophenol, pentachloroanisole, tetrachlorohydroquinone, tetrachlorocatechol, tetrachlororesorcinol, tetrachlorodimethoxybenzenes and tetrachlorobenzenediol diacetates administered to mice, Toxicological & Environmental Chemistry, 11:1, 37-50.

[2]. Mukherjee, et al. Evaluation of Acute Toxicity Levels and Ethological Responses Under Tetrachlorocatechol Exposure in Common Carp, Cyprinus carpio (Linnaeus). Proc Zool Soc 67, 108–113 (2014).

四氯邻苯二酚物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
309.1±37.0 °C at 760 mmHg

[ 熔点 ]:
184-186°C (dec.)

[ 分子式 ]:
C₆H₂Cl₄O₂

[ 分子量 ]:
247.891

[ 闪点 ]:
140.7±26.5 °C

[ 精确质量 ]:
245.880890

[ PSA ]:
40.46000

[ LogP ]:
4.74

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.662

[ 储存条件 ]:
2-8°C

四氯邻苯二酚MSDS

四氯邻苯二酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX2449000

CHEMICAL NAME :: Pyrocatechol, tetrachloro-

CAS REGISTRY NUMBER :: 1198-55-6

BEILSTEIN REFERENCE NO. :: 1876366

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H2-Cl4-O2

MOLECULAR WEIGHT :: 247.88

WISWESSER LINE NOTATION :: QR BQ CG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,526,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,526,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 11,37,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,63,1978

四氯邻苯二酚安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/22

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S39

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
UX2449000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2908199090

四氯邻苯二酚合成路线

四氯邻苯二酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

四氯邻苯二酚文献

Polyhalogenated benzo- and naphthoquinones are potent inhibitors of plant and bacterial ureases.

FEBS Lett. 555(2) , 367-70, (2003)

Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobact...

Oxidative double dehalogenation of tetrachlorocatechol by a bio-inspired CuII complex: formation of chloranilic acid.

Chemistry 14(18) , 5567-76, (2008)

Copper(II) complexes of the potentially tripodal N,N,O ligand 3,3-bis(1-methylimidazol-2-yl)propionate (L1) and its conjugate acid HL1 have been synthesised and structurally and spectroscopically char...

Synergistic cytotoxic effect of tetrachlorocatechol and sodium azide in Escherichia coli: toxicity, metabolism, and mechanistic aspects.

Environ. Toxicol. Chem. 28(7) , 1380-9, (2009)

Pentachlorophenol (PCP) is used in industrial and domestic applications, including as a biocide and a wood preservative. Metabolism of PCP undergoes oxidative dechlorination, forming tetrachlorocatech...

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