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N-乙酰-L-谷氨酸

N-乙酰-L-谷氨酸用途

N-Acetyl-L-glutamic acid 是一种N-acyl-L-氨基酸,是动物细胞培养基的组成成分。N-Acetyl-L-glutamic acid 是酿酒酵母和人类的代谢物。

N-乙酰-L-谷氨酸名称

[ CAS 号 ]:
1188-37-0

[ 中文名 ]:
N-乙酰-L-谷氨酰胺

[ 英文名 ]:
N-Acetyl-L-glutamic acid

[中文别名 ]:

[英文别名 ]:

(2S)-2-(acetylamino)pentanedioic acid
EINECS 214-708-4
N-Acetyl-L-glutamicacid
AC-GLU-OH
N-acetyl-L-glutamate
(S)-2-acetamidopentanedioic acid
N-ACETYL-L-GLU
N-AC-L-GLU
MFCD00002802
N-Acetyl-L-Glutamic

N-乙酰-L-谷氨酸生物活性

[ 描述 ]:

N-Acetyl-L-glutamic acid 是一种N-acyl-L-氨基酸,是动物细胞培养基的组成成分。N-Acetyl-L-glutamic acid 是酿酒酵母和人类的代谢物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. M Hashimoto, et al. Animal cell culturing media containing N-acetyl-L-glutamic acid. Patent.

N-乙酰-L-谷氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
495.9±35.0 °C at 760 mmHg

[ 熔点 ]:
194-196 °C(lit.)

[ 分子式 ]:
C₇H₁₁NO₅

[ 分子量 ]:
189.166

[ 闪点 ]:
253.7±25.9 °C

[ 精确质量 ]:
189.063721

[ PSA ]:
103.70000

[ LogP ]:
-2.24

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
2.7 g/100 mL (20 ºC)

N-乙酰-L-谷氨酸MSDS

N-乙酰-L-谷氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ9725000

CHEMICAL NAME :: L-Glutamic acid, N-acetyl-

CAS REGISTRY NUMBER :: 1188-37-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H11-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6838 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 711 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

N-乙酰-L-谷氨酸安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LZ9725000

[ 海关编码 ]:
29241900

N-乙酰-L-谷氨酸合成路线

N-乙酰-L-谷氨酸上下游产品

N-乙酰-L-谷氨酸上游产品

N-乙酰-L-谷氨酸下游产品

N-乙酰-L-谷氨酸海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-乙酰-L-谷氨酸文献

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.

Anal. Chem. 83(7) , 2705-11, (2011)

Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few inter...

Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Clin. Biochem. 38(11) , 997-1008, (2005)

To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemi...

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