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靛红酸酐

靛红酸酐用途

用作医药、农药、染料的原料，是除草剂苯达松的重要中间体

靛红酸酐名称

[ CAS 号 ]:
118-48-9

[ 中文名 ]:
靛红酸酐

[ 英文名 ]:
Isatoic anhydride

[中文别名 ]:

[英文别名 ]:

2H-3,1-Benzoxazine-2,4(1H)-dione
Anthranilic acid N-carboxylic acid anhydride
Isatoic anhydride
3,1-Benzoxazine-2,4(1H)-dione
1H-3,1-benzoxazine-2,4-dione
1H-Benzo[d][1,3]oxazine-2,4-dione
Isatoic acid anhydride
T66 BMVOVJ
Benzoic acid, 2-(carboxyamino)-, cyclic anhydride
Benzoxazinedione

靛红酸酐物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
233 °C (dec.)(lit.)

[ 分子式 ]:
C₈H₅NO₃

[ 分子量 ]:
163.130

[ 闪点 ]:
308 °C

[ 精确质量 ]:
163.026947

[ PSA ]:
63.07000

[ LogP ]:
0.90

[ 外观性状 ]:
黄褐色粉末

[ 蒸汽密度 ]:
5.6 (vs air)

[ 折射率 ]:
1.586

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

[ 水溶解性 ]:
decomposes

靛红酸酐MSDS

靛红酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3100000

CHEMICAL NAME :: 2H-3,1-Benzoxazine-2,4(1H)-dione

CAS REGISTRY NUMBER :: 118-48-9

BEILSTEIN REFERENCE NO. :: 0136786

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H5-N-O3

MOLECULAR WEIGHT :: 163.14

WISWESSER LINE NOTATION :: T66 BMVOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 34800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966

靛红酸酐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36;R43

[ 安全声明 (欧洲) ]:
S24-S26-S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
DM3100000

[ 海关编码 ]:
2934999090

靛红酸酐合成路线

靛红酸酐上下游产品

靛红酸酐上游产品

靛红酸酐下游产品

靛红酸酐制备

由邻氨基苯甲酸与光气反应而得。将邻氨基苯甲酸溶解于热水和浓盐酸中，在搅拌下通入光气，靛红酸酐立即析出。反应放热，调节光气通入速度，使温度不超过50℃。连续通入光气2-4h，至吸收速度显著减慢为止。将产物在空气中晾干，于100℃干燥即得成品。

靛红酸酐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靛红酸酐文献

Hydrogen-bonding in 2-aminobenzoyl-alpha-chymotrypsin formed by acylation of the enzyme with isatoic anhydride: IR and mass spectroscopic studies.

ChemBioChem. 3(1) , 68-75, (2002)

The acyl-enzyme formed upon acylation of alpha-chymotrypsin with isatoic anhydride has been characterised by infrared spectroscopy. Acylation at pH 7 to yield the 2-aminobenzoyl-enzyme is rapid (k = 5...

Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids.

Org. Lett. 13 , 6114-6117, (2011)

The decarboxylative coupling of isatoic anhydrides with arylboronic acids was realized for the first time in the presence of Pd(2)(dba)(3) and DPEphos, achieving aryl o-aminobenzoates with yields rang...

1,3-Dipolar cycloaddition-decarboxylation reactions of an azomethine ylide with isatoic anhydrides: formation of novel benzodiazepinones.

Org. Lett. 13(3) , 486-9, (2011)

A nonstabilized azomethine ylide reacts with a wide range of substituted isatoic anhydrides to afford novel 1,3-benzodiazepin-5-one derivatives, which are generally isolated in high yield. The transfo...

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