<生产厂家价格>

辛可宁

辛可宁用途

Cinchonine 是金鸡纳树皮中的天然化合物。Cinchonine 可激活内质网应激诱导的人肝癌细胞凋亡。

辛可宁名称

[ CAS 号 ]:
118-10-5

[ 中文名 ]:
辛可宁

[ 英文名 ]:
Cinchonine

[中文别名 ]:

[英文别名 ]:

homoquinidine
MFCD00064372
EINECS 204-234-6
cinchonidine
chinchonine
Cinchonine
Cinchonan-9-ol, (8α,9S)-
D-CINCHONINE
Cinchonin
(8α,9S)-Cinchonan-9-ol

辛可宁生物活性

[ 描述 ]:

Cinchonine 是金鸡纳树皮中的天然化合物。Cinchonine 可激活内质网应激诱导的人肝癌细胞凋亡。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

辛可宁物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
464.5±30.0 °C at 760 mmHg

[ 熔点 ]:
260-263 °C

[ 分子式 ]:
C₁₉H₂₂N₂O

[ 分子量 ]:
294.39

[ 闪点 ]:
234.7±24.6 °C

[ 精确质量 ]:
294.173218

[ PSA ]:
36.36000

[ LogP ]:
3.35

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.652

[ 储存条件 ]:
避免光

[ 水溶解性 ]:
Insoluble

辛可宁MSDS

辛可宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD3500000

CHEMICAL NAME :: Cinchonine

CAS REGISTRY NUMBER :: 118-10-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H22-N2-O

MOLECULAR WEIGHT :: 294.43

WISWESSER LINE NOTATION :: T66 BNJ EYQ- DT66 A B CNTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

辛可宁安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H332

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S36-S36/37

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ RTECS号 ]:
GD3500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

辛可宁合成路线

辛可宁上下游产品

辛可宁上游产品

辛可宁下游产品

辛可宁制备

1.植物来源有茜草科植物红色金鸡纳树的树皮，金鸡纳的树皮等。也可以生物合成，可制成盐酸盐和酒石酸盐。具有抗疟原虫和解热作用。

2. 金鸡纳树皮经萃取可得生物碱，其粗品以硝酸溶解，再用氨水沉淀，所得白色沉淀即为辛可宁。

辛可宁海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

辛可宁文献

Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.

Bioorg. Med. Chem. 18 , 2225-31, (2010)

There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one pa...

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.

Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...

Thousands of chemical starting points for antimalarial lead identification.

Nature 465 , 305-10, (2010)

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 19...

更多文献

辛可宁